167393-62-6

Basic information

• Product Name: Fmoc-N'-methyltrityl-L-lysine
• Synonyms: FMOC-L-LYS(MMT)-OH;FMOC-L-LYS(MTT)-OH;FMOC-LYS(CH3TRT)-OH;FMOC-LYSINE(4-METHOXYTRITYL)-OH;FMOC-LYSINE(MTT)-OH;FMOC-LYS(MEOTRT)-OH;FMOC-LYS(MMT)-OH;FMOC-LYS(4-METHOXYTRITYL)-OH
• CAS NO: 167393-62-6
• Molecular Formula: C41H40N2O4
• Molecular Weight: 624.77
• Product Categories: Amino Acids;Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series;amino acid
• Mol File: 167393-62-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 140 °C(dec.)
• Boiling Point: 798.78 °C at 760 mmHg
• Flash Point: 436.887 °C
• Appearance: /Solid
• Density: 1.198 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: -20°C
• PKA: 3.83±0.21(Predicted)
• CAS DataBase Reference: Fmoc-N'-methyltrityl-L-lysine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-N'-methyltrityl-L-lysine(167393-62-6)
• EPA Substance Registry System: Fmoc-N'-methyltrityl-L-lysine(167393-62-6)

Safety Data

• Hazardous Substances Data: 167393-62-6(Hazardous Substances Data)

Usage

Description

Fmoc-N'-methyltrityl-L-lysine, also known as Fmoc-Lys(Mtt)-OH, is an amino acid derivative that plays a crucial role in chemical synthesis and peptide chemistry. It is characterized by its white to off-white powder form and the presence of the side-chain Mtt group, which can be selectively removed using specific reagents, making it an excellent derivative for various applications in the field of peptide synthesis.

Uses

Used in Chemical Synthesis and Peptide Chemistry:
Fmoc-N'-methyltrityl-L-lysine is used as a key component in the synthesis of branched peptides and peptides modified at the lysine side-chain. The selective removal of the Mtt group using 1% TFA in DCM or a mixture of DCM/HFIP/TFE/TES facilitates the construction of complex peptide structures and allows for the development of multifunctionalized resins for combinatorial synthesis.
Used in the Construction of Templates and Multifunctionalized Resins:
Fmoc-N'-methyltrityl-L-lysine is employed as a building block for the creation of templates and multifunctionalized resins, which are essential for combinatorial synthesis. These templates and resins enable the efficient and systematic exploration of peptide libraries, leading to the discovery of novel bioactive peptides with potential applications in various fields, such as pharmaceuticals, diagnostics, and therapeutics.
Used in the Synthesis of Branched Peptides:
Fmoc-N'-methyltrityl-L-lysine is utilized as a crucial intermediate in the synthesis of branched peptides, which are peptides with multiple chains branching off from a central point. These branched peptides have unique structural and functional properties that make them valuable in various applications, including drug design, protein engineering, and the development of novel biomaterials.
Used in Peptide Modification:
Fmoc-N'-methyltrityl-L-lysine is used as a versatile building block for the modification of peptides at the lysine side-chain. This modification can alter the properties of the peptide, such as its solubility, stability, and biological activity, making it suitable for various applications, including the development of new drugs, the creation of targeted drug delivery systems, and the design of novel diagnostic tools.

InChI:InChI=1/C41H40N2O4/c1-29-23-25-32(26-24-29)41(30-14-4-2-5-15-30,31-16-6-3-7-17-31)42-27-13-12-22-38(39(44)45)43-40(46)47-28-37-35-20-10-8-18-33(35)34-19-9-11-21-36(34)37/h2-11,14-21,23-26,37-38,42H,12-13,22,27-28H2,1H3,(H,43,46)(H,44,45)/t38-/m0/s1