1675201-83-8 Usage
Description
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)is a complex organic compound with a unique molecular structure. It is characterized by its piperidinecarboxylic acid core, which is further modified by a series of methoxy and methyl substitutions on a biphenyl moiety. 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)is likely to have specific applications in various industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
In the field of chemical research, 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)can be used as a starting material for the synthesis of novel compounds with potential applications in various industries, such as materials science, agrochemicals, and environmental science.
Used in Cancer Treatment:
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)is used as a PD-L1 inhibitor in combination with LIF inhibitors for the treatment of cancers. It works by inhibiting the formation of the PD-1/PD-L1 complex, which is essential for cancer cells to evade the immune system. 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)can potentially enhance the effectiveness of cancer immunotherapies and improve patient outcomes.
in vitro
pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].
IC 50
0.006-0.10 μm
References
1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820
Check Digit Verification of cas no
The CAS Registry Mumber 1675201-83-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,7,5,2,0 and 1 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1675201-83:
(9*1)+(8*6)+(7*7)+(6*5)+(5*2)+(4*0)+(3*1)+(2*8)+(1*3)=168
168 % 10 = 8
So 1675201-83-8 is a valid CAS Registry Number.
1675201-83-8Relevant articles and documents
COMPOUNDS WITH IMMUNOMODULATORY ACTIVITY AND THERAPEUTIC USES THEREOF
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Paragraph 00126; 00170, (2021/09/17)
The present invention generally relates to new compounds for therapeutic uses. In particular, the disclosed series compounds with immunomodulatory activities are useful for treatment of dysfunctions of the immune system and various cancers. Pharmaceutical composition matters and methods for treating a patient with an immune disease and/or a cancer by administering therapeutically effective amounts of such compound alone or together with other therapeutics are within the scope of this disclosure.
