167637-41-4 Usage
Description
Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate is a chemical compound that serves as an intermediate in the synthesis of various analogs of retinoid lactone. It is characterized by its orange-yellow oily residue appearance.
Uses
Used in Pharmaceutical Industry:
Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate is used as an intermediate for the synthesis of analogs of retinoid lactone. This application is due to its role in creating compounds that can potentially have therapeutic effects, particularly in the treatment of various skin conditions and other health-related issues.
Used in Chemical Synthesis:
Ethyl-5-(4-methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienoate is also used as an intermediate in chemical synthesis for various other applications. Its unique chemical structure allows it to be a valuable component in the creation of different compounds, contributing to its versatility in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 167637-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,6,3 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 167637-41:
(8*1)+(7*6)+(6*7)+(5*6)+(4*3)+(3*7)+(2*4)+(1*1)=164
164 % 10 = 4
So 167637-41-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O3/c1-7-21-18(19)10-12(2)8-9-16-13(3)11-17(20-6)15(5)14(16)4/h8-11H,7H2,1-6H3/b9-8+,12-10+
167637-41-4Relevant articles and documents
Evaluation of retinoid lactones as topical therapeutic agents in dermatology
Lewin,Black,Bos,Goehring,Nair,Whiting,Bouquin,Tetrault,Carroll
, p. 983 - 992 (1995)
Purpose. Optimization of the therapeutic ratio of analogs of the topically active 11-cis,13-cis-12-hydroxymethylretinoic acid, δ-lactone (I) relative to antihyperproliferation and antihyperkeratinization vs. toxicity. Methods. Nine analogs of 1, in which variations were made in the lipophilic cyclohexenyl moiety or in the lactone ring, were evaluated for topical activity against hyperkeratinization, inhibition of TPA-induced DNA synthesis and for skin irritation. Results. Although more potent lactones than the parent lactone 1 were identified, none possessed the favorable therapeutic ratio associated with 1. Conclusions. The δ-lactone 1 possesses unique molecular features responsible for its desirable therapeutic ratio as an anti-hyperproliferative and antihyperkeratotic agent. In view of its very low systemic retinoid toxicity and the absence of any systemic toxicity, this lactone may be a good candidate for use in the topical treatment of acne.