16765-45-0

Basic information

• Product Name: erythro-phenyl(tetrahydrofuran-2-yl)methanol
• CAS NO: 16765-45-0
• Molecular Weight: 178.231
• Mol File: 16765-45-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: erythro-phenyl(tetrahydrofuran-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-phenyl(tetrahydrofuran-2-yl)methanol(16765-45-0)
• EPA Substance Registry System: erythro-phenyl(tetrahydrofuran-2-yl)methanol(16765-45-0)

Safety Data

• Hazardous Substances Data: 16765-45-0(Hazardous Substances Data)

Upstream product

• 13544-26-8 6-phenyl-3,4-dihydro-2H-pyran 
• 4203-44-5 2-phenyltetrahydropyran 
• 141957-79-1 phenyl(tetrahydrofuran-2-yl)methanone 
• 93903-57-2 (E)-5-phenylpent-4-en-1-yl 4-methylbenzenesulfonate 
• 109-99-9 tetrahydrofuran 
• 100-52-7 benzaldehyde 
• 5331-61-3 gem-diacetate de tetrahydrofurfural 
• 7681-84-7 tetrahydrofuran-2-carbaldehyde 

Relevant articles and documents

Ring-Contraction Reaction of Substituted Tetrahydropyrans via Dehydrogenative Dual Functionalization by Nitrite-Catalyzed Double Activation of Bromine

A nitrite-catalyzed ring contraction reaction of substituted tetrahydrofurans by oxidation of bromide under aerobic conditions as a dehydrogenative dual functionalization was developed to provide 2-acyltetrahydrofurans in good yields. On the other hand, the oxidation reaction of 1-substituted isochromans occurred via the bromohydroxylation to give 1-(dibromoalkyl)-1-hydroxyisochromans in high yields.

Chemoselective oxygen-centered radical cyclizations onto silyl enol ethers

(Chemical Equation Presented) A new oxygen-centered radical cyclization onto silyl enol ethers has been developed and utilized for the synthesis of versatile siloxy-substituted tetrahydrofurans. The reactions display excellent chemoselectivity for cyclization onto the electron-rich silyl enol ether when competing terminal alkene cyclization, 1,5-hydrogen abstraction, and β-fragmentation pathways are present. The increased chemoselectivity also allows for the synthesis of tetrahydropyrans, a challenging substrate class to access using oxygen-centered radical alkene cyclizations due to competing 1, 5-hydrogen abstractions.

New method for the synthesis of α-substituted tetrahydrofuran -2-methanols through diastereoselective addition of THF to aldehydes mediated by Et3B in the presence of air

The tetrahydrofuranyl radical, generated from THF with Et3B in the presence of air, was found to react with aldehydes threo-selectively to afford α-substituted tetrahydrofuran-2-methanols, the common structural motifs of biologically active ace