167683-61-6 Usage
Description
1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]thiourea is a complex organic chemical compound characterized by a pyridine ring with a bromine substituent. This ring is connected to a thiourea moiety through an ethyl group and a phenyl ring, which itself features chlorine and fluorine substituents along with an ethoxy group. As a thiourea derivative, this compound holds potential biological and pharmacological activities, although the specific applications and effects are not explicitly detailed in the provided name. Thiourea derivatives, in general, have been investigated for their possible roles in antifungal, antibacterial, and anticancer treatments, as well as their utility in the synthesis of various organic compounds and materials.
Uses
Given the general properties of thiourea derivatives, potential applications for 1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]thiourea could include:
Used in Pharmaceutical Industry:
1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]thiourea could be used as a pharmaceutical agent for its potential antifungal, antibacterial, and anticancer properties. 1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]thiourea's unique structure may allow it to interact with specific biological targets, providing a basis for therapeutic development.
Used in Material Science:
In the field of material science, 1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-fluorophenyl)ethyl]thiourea might be utilized in the synthesis of novel organic compounds or materials, leveraging its structural diversity and potential reactivity.
Used in Chemical Research:
As a thiourea derivative with a unique structure, this compound could serve as a subject of interest in chemical research, potentially leading to the discovery of new reactions or applications in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 167683-61-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,6,8 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 167683-61:
(8*1)+(7*6)+(6*7)+(5*6)+(4*8)+(3*3)+(2*6)+(1*1)=176
176 % 10 = 6
So 167683-61-6 is a valid CAS Registry Number.
167683-61-6Relevant articles and documents
Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs
Cantrell, Amanda S.,Engelhardt, Per,H?gberg, Marita,Jaskunas, S. Richard,Johansson, Nils Gunnar,Jordan, Christopher L.,Kangasmets?, Jussi,Kinnick, Michael D.,Lind, Peter,Morin Jr., John M.,Muesing,Noreén, Rolf,?berg, Bo,Pranc, Paul,Sahlberg, Christer,Ternansky, Robert J.,Vasileff, Robert T.,Vrang, Lotta,West, Sarah J.,Zhang, Hong
, p. 4261 - 4274 (2007/10/03)
Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of nonnucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea hydrochloride (trovirdine; LY300046.HCl) as a highly potent anti-HIV-1 agent. Trovirdine is currently in phase one clinical trials for potential use in the treatment of AIDS. Extension of these structure-activity relationship studies to identify additional compounds in this series with improved properties is ongoing. A part of this work is described here. Replacement of the two aromatic moleties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated. In addition, the effects of multiple substitution in the phenyl ring were also studied. The antiviral activities were determined on wild-type and constructed mutants of HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell culture assays. Some selected compounds were determined on double- mutant viruses, HIV-1 (Ile100/Asn103) and HIV-1 (Ile100/Cys181). A number of highly potent analogs were synthesized. These compounds displayed IC50's against wild-type RT between 0.6 and 5 nM. In cell culture, these agents inhibited wild-type HIV-1 with ED50's between I and 5 nM in MT-4 cells. In addition, these derivatives inhibited mutant HIV-1 RT (Ile 100) with IC50's between 20 and 50 nM and mutant HIV-1 RT (Cys 181) with IC50's between 4 and 10 nM, and in cell culture they inhibited mutant HIV-1 (Ile100) with ED50's between 9 and 100 nM and mutant HIV-1 (Cys181) with ED50's between 3 and 20 nM.
