167855-66-5

Basic information

• Product Name: 2-(2-nitro-4-trifluoromethylphenoxy)isobutyraldehyde
• Synonyms: 2-(2-nitro-4-trifluoromethylphenoxy)isobutyraldehyde
• CAS NO: 167855-66-5
• Molecular Weight: 277.2
• Mol File: 167855-66-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-nitro-4-trifluoromethylphenoxy)isobutyraldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-nitro-4-trifluoromethylphenoxy)isobutyraldehyde(167855-66-5)
• EPA Substance Registry System: 2-(2-nitro-4-trifluoromethylphenoxy)isobutyraldehyde(167855-66-5)

Safety Data

• Hazardous Substances Data: 167855-66-5(Hazardous Substances Data)

Upstream product

• 13206-46-7 2-bromo-2-methylpropanal 
• 400-99-7 2-nitro-4-trifluoromethylphenol 

Relevant articles and documents

Novel potassium channel activators: Synthesis and structure-activity relationship studies of 3,4-dihydro-2H-1,4-benzoxazine derivatives

Strong potassium channel-activating effects were found among a series of novel 4-substituted 3,4-dihydro-2H-1,4-benzoxazine derivatives. The key step in preparation was the nucleophilic substitution of 3,4-dihydro-2H-1,4- benzoxazine (3) with activated halogenopyridines, such as halogenopyridine N- oxides (15a-c) and the borane adduct (15d) of 4-bromopyridine. Structure- activity relationship studies identified 2-(3,4-dihydro-2,2-dimethyl-6- nitro-2H-1,4-benzoxazin-4-yl)pyridine-1-oxide (16a: YM934) as the optimal compound. This compound (16a) showed a more potent oral antihypertensive effect than cromakalim in conscious spontaneously hypertensive rats.