16790-59-3Relevant articles and documents
Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring
Wallgren, Jakob,Vikingsson, Svante,Johansson, Anders,Josefsson, Martin,Green, Henrik,Dahlén, Johan,Wu, Xiongyu,Konradsson, Peter
, p. 1456 - 1458 (2017)
Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring.
Ring-fused compound, pharmaceutical composition containing same and application of compound
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, (2018/04/01)
The invention discloses a ring-fused compound, a preparation method thereof, pharmaceutical composition containing the compound and an application of the compound. A polycyclic compound (I) as well asan isomer, a prodrug, a stable isotopic derivative or pharmacologically acceptable salt of the compound (I) has the following structure. The polycyclic compound has good IDO1 and/or TDO2 inhibition functions, can effectively treat, relieve and/or prevent various diseases which are related with IDO1 and/or TDO2, such as cancer, virus infection, autoimmune diseases or the like.