167933-61-1Relevant articles and documents
The catalytic asymmetric abramov reaction
Guin, Joyram,Wang, Qinggang,Van Gemmeren, Manuel,List, Benjamin
supporting information, p. 355 - 358 (2015/04/27)
The first catalytic enantioselective Abramov reaction is described. The process is based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids the difficulties encountered with metal-based catalysts. Several functionalized a-hydroxy phosphonates were synthesized in good yields and with excellent enantiomeric ratios of up to > 99:1. The process was shown to be scalable and up to 1 g of starting material could be employed under mild reaction conditions.
Asymmetric Synthesis of Chiral, Nonracemic Dialkyl-α-, β-, and γ-Hydroxyalkylphosphonates via a Catalyzed Enantioselective Catecholborane Reduction
Meier, Chris,Laux, Wolfgang H. G.
, p. 1089 - 1092 (2007/10/02)
A highly enantioselective synthesis of dialkyl α-hydroxyphosphonates achieved by a oxazaborolidine catalyzed reduction with catecholborane starting with α-ketophosphonates is described.Both α-aryl- and α-alkylketophosphonates were reduced using the (S)-en
