167969-10-0

Basic information

• Product Name: (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide
• Synonyms: (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide
• CAS NO: 167969-10-0
• Molecular Weight: 424.5
• Mol File: 167969-10-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide(167969-10-0)
• EPA Substance Registry System: (Z)-N-benzyloxycarbonyl-D-(p-amidoximo-phenylalanine) piperidide(167969-10-0)

Safety Data

• Hazardous Substances Data: 167969-10-0(Hazardous Substances Data)

Upstream product

• 263396-44-7 (2R)-2-amino-3-(4-cyanophenyl)propanoic acid 
• 167969-09-7 N-[(benzyloxy)carbonyl]-4-cyano-D-phenylalanine 
• 146664-09-7 N-acetyl-D- 
• 172267-41-3 2-acetylamino-(Z)- 
• 105-07-7 4-cyanobenzaldehyde 
• 94929-80-3 (Z)-<4-p-cyanophenylmethylene>-2-methyl-oxazol-5-one 
• 501-53-1 benzyl chloroformate 
• 110-89-4 piperidine 
• 168039-92-7 N-benzyloxycarbonyl-D-(p-cyanophenylalanine) piperidide 

Relevant articles and documents

Efficient Kg-Scale Synthesis of Thrombin Inhibitor CRC 220

Potent thrombin inhibitor 2 is prepared in 10 steps with 20percent overall yield from commercial 4 on a kg-scale by the convergent approach depicted in Schemes 1 and 2.The (R)-configuration of the 4-amidinophenylalanine piperidide moiety is controlled by asymmetric hydrogenation.A novel method, the hydrogenolysis of amidoximes 11 and 21, is employed to attain a particularly clean transformation of the cyano into the amidinium functionality.Despite of the amorphous nature of target compound 2, the approach is devoid of any chromatographic purification.