16803-75-1
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Basic information
- Product Name: BROMAMPHENICOL
- Synonyms: Acetamide, 2,2-dibromo-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
- CAS NO:16803-75-1
- Molecular Formula: C11H12Br2N2O5
- Molecular Weight: 412.033
- EINECS: N/A
- Product Categories: N/A
- Mol File: 16803-75-1.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: BROMAMPHENICOL(CAS DataBase Reference)
- NIST Chemistry Reference: BROMAMPHENICOL(16803-75-1)
- EPA Substance Registry System: BROMAMPHENICOL(16803-75-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 16803-75-1(Hazardous Substances Data)
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16803-75-1 Usage
Description
Bromamphenicol, a semi-synthetic chloramphenicol analogue first reported in 1950, is characterized by the replacement of dichloroacetamide with dibromoacetamide. It exhibits weak antibiotic activity and has been instrumental in comparative crystallography studies with chloramphenicol, which helped define the structure-activity relationships (SARs) of the acetamide binding region on the ribosome. Furthermore, recent research has utilized this relationship to demonstrate that chloramphenicol binding to DraE virulence factors in Gram-negative bacteria is independent of the chloramphenicol binding site on the ribosome.Uses
Used in Pharmaceutical Industry:Bromamphenicol is used as a semi-synthetic chloramphenicol analogue for its weak antibiotic activity. It serves as a valuable tool in comparative crystallography studies with chloramphenicol, aiding in the understanding of the structure-activity relationships of the acetamide binding region on the ribosome. This knowledge is crucial for the development of new antibiotics and the improvement of existing ones.
Additionally, Bromamphenicol is used in research to demonstrate the independence of chloramphenicol binding to DraE virulence factors in Gram-negative bacteria from the chloramphenicol binding site on the ribosome. This insight is vital for advancing the understanding of bacterial resistance mechanisms and the development of more effective treatments against antibiotic-resistant infections.
Check Digit Verification of cas no
The CAS Registry Mumber 16803-75-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,0 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.Calculate Digit Verification of CAS Registry Number 16803-75:
(7*1)+(6*6)+(5*8)+(4*0)+(3*3)+(2*7)+(1*5)=111
111 % 10 = 1
So 16803-75-1 is a valid CAS Registry Number.
16803-75-1Upstream product
16803-75-1Downstream Products
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