16807-11-7

Basic information

• Product Name: 1-broMo-9H-carbazole
• Synonyms: 1-broMo-9H-carbazole;9H-Carbazole, 1-broMo-;1-broMocarbazole;-broMo-9H-carbazole
• CAS NO: 16807-11-7
• Molecular Formula: C₁₂H₈BrN
• Molecular Weight: 246.10262
• Mol File: 16807-11-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 123-124℃ (acetic acid )
• Boiling Point: 409.2±18.0 °C(Predicted)
• Appearance: /
• Density: 1.617±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.14±0.30(Predicted)
• CAS DataBase Reference: 1-broMo-9H-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-broMo-9H-carbazole(16807-11-7)
• EPA Substance Registry System: 1-broMo-9H-carbazole(16807-11-7)

Safety Data

• Hazardous Substances Data: 16807-11-7(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow powder or crystals.

Uses

1-Bromo-9H-carbazole is a useful research chemical, mainly used as a pharmaceutical intermediate and an intermediate in organic synthesis.

Preparation

A 1-Bromo-9H-carbazole is synthesized as follows：Under noble gas protection, by 3,6- bis- Tert-butyl carbazole is dissolved in 1,2- dichloroethanes, adds hydrobromic acid, controlling reaction temperature to be slowly added dropwise hydrogen peroxide, dropping is completely Overnight, reactant liquor is washed, and separates organic layer for natural temperature reaction, is dried, and adds methyl alcohol dispersion, obtains the tertiary fourth of bromo- 3, the 6- of 1- bis- Base carbazole；Then 1- bromo- 3,6- di-t-butyl carbazole and isopropanol solvent are added in reaction bulb, controlling reaction temperature slowly adds Enter alchlor reaction, add water after terminating terminating reaction, through extraction, organic layer sodium hydrate aqueous solution is washed, and is dried overnight, concentrate Obtain crude product, methylene chloride-methanol mixed solvent is recrystallized to give product 1-Bromo-9H-carbazole.Production method of 1-bromocarbazole

Upstream product

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Downstream Products

• 1365549-01-4 10-(9H-carbazol-3-yl)-7-phenyl-7H-benzo[c]carbazole 
• 1337956-17-8 9-benzenesulfonyl-1-bromo-9H-carbazole 
• 1337956-18-9 methyl 9-benzenesulfonyl-9H-[1,9']bicarbazolyl-1'-carboxylate 
• 1337956-25-8 2-[2-(9H-carbazol-1-ylamino)phenyl]propan-2-ol 
• 1337956-24-7 methyl 2-(9H-carbazol-1-ylamino)benzoate 
• 1219637-88-3 1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9H-carbazole 
• 1333002-41-7 (9-phenyl-9H-carbazole-1-yl)boronic acid 

Relevant articles and documents

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Method for synthesizing 1-bromocarbazole by taking carbazole as raw material

The invention discloses a method for synthesizing 1-bromocarbazole by taking carbazole as a raw material. The method comprises the following steps: mixing carbazole as a raw material with an acylation reagent, a catalyst and a reaction solvent, and carrying out acylation reaction to obtain an N-H substituted carbazole intermediate; forming a reaction system by using the carbazole intermediate obtained in the step (1) and a reaction solvent, dropwise adding a lithiation reagent to perform a lithium substitution reaction, and dropwise adding a bromination reagent to perform a bromination reaction after the reaction is completed to obtain a carbazole N-substituted 1-position bromination product; and (3) carrying out hydrolysis deprotection reaction on the carbazole N-substituted 1-position brominated product obtained in the step (2) to obtain a 1-bromocarbazole product. According to the method, phosphorus-containing compounds with serious pollution do not need to be used, the adopted raw material carbazole is easy to obtain and low in cost, post-treatment operation is simple and easy, the post-treatment cost is low, the problems that existing 1-bromocarbazole is high in production cost, complex in synthesis technological process, more in three wastes and heavy in pollution can be solved, the purity of the obtained 1-bromocarbazole is 99.5% or above, the obtained 1-bromocarbazole is high in purity, and the yield can reach more than 80%.

ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

An organometallic compound represented by Formula 1: wherein, in Formula 1, groups and variables are the same as described in the specification.