16820-39-6

Basic information

• Product Name: 3,6-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE
• Synonyms: AKOS BBS-00000040;3,6-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE;IFLAB-BB F3055-0619;2-BENZOFURANCARBOXALDEHYDE, 3,6-DIMETHYL-;3,6-DIMETHYL-1-BENZOFURAN-2-CARBALDEHYDE;3,6-DIMETHYL-2-BENZOFURANCARBOXALDEHYDE;AKOS A0602-0087;OTAVA-BB 7118560415
• CAS NO: 16820-39-6
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.2
• Mol File: 16820-39-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 76-78 °C(Solv: methanol, 80% (67-56-1))
• Boiling Point: 295.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.157±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,6-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE(16820-39-6)
• EPA Substance Registry System: 3,6-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE(16820-39-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16820-39-6(Hazardous Substances Data)

Upstream product

• 24410-50-2 3,6-dimethylbenzofuran 
• 74-90-8 hydrogen cyanide 
• 16820-38-5 3,6-Dimethyl-benzofuran-2-carbonyl chloride 
• 27408-69-1 ethyl 2-acetyl-5-methylphenoxyacetate 
• 83406-17-1 (2-acetyl-5-methyl-phenoxy)-acetic acid 
• 16820-37-4 6-methyl-3-methylcoumarilic acid 
• 16820-36-3 3,6-dimethyl-benzofuran-2-carboxylic acid ethyl ester 
• 108-39-4 3-methyl-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 702-69-2 7-methyl-1,4-dioxa-spiro[4.5]decan-8-one 

Downstream Products

• 58455-69-9 4-(3,6-dimethyl-benzofuran-2-ylmethylene)-2-phenyl-4H-oxazol-5-one 
• 16820-37-4 6-methyl-3-methylcoumarilic acid 
• 87487-47-6 (E)-3-(3,6-Dimethyl-benzofuran-2-yl)-1-(2-hydroxy-4-methyl-phenyl)-propenone 
• 87487-48-7 (E)-3-(3,6-Dimethyl-benzofuran-2-yl)-1-(2-hydroxy-5-methyl-phenyl)-propenone 
• 87487-46-5 (E)-1-(5-Chloro-2-hydroxy-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-53-4 (E)-1-(2-Benzyloxy-5-methyl-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-56-7 (E)-1-(2-Benzyloxy-5-chloro-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-45-4 (E)-1-(5-Bromo-2-hydroxy-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-58-9 (E)-1-(2-Benzyloxy-4-methoxy-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-57-8 (E)-1-(2-Benzyloxy-4-methyl-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-55-6 (E)-1-(2-Benzyloxy-5-bromo-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 87487-54-5 (E)-1-(2-Benzyloxy-4,5-dimethyl-phenyl)-3-(3,6-dimethyl-benzofuran-2-yl)-propenone 
• 16820-43-2 Benzoylamino-(3,6-dimethyl-benzofuran-2-yl)-acetic acid 

Relevant articles and documents

A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols

An interesting albeit unexpected deviation during attempted Tanabe γ-lactone annulation on 4-hydroxycyclohexanones has led to a general, one-pot synthesis of benzofurans and naphtho[2,3–b]furans from readily assembled precursors. The utility of this adaptable methodology has been demonstrated through concise syntheses of natural products, stereumene B, paeoveitol D and (±)-paeoveitol.