16825-77-7

Basic information

• Product Name: Benzene, 1-iodyl-2-nitro-
• CAS NO: 16825-77-7
• Molecular Formula: C6H4INO4
• Molecular Weight: 281.007
• Mol File: 16825-77-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-iodyl-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-iodyl-2-nitro-(16825-77-7)
• EPA Substance Registry System: Benzene, 1-iodyl-2-nitro-(16825-77-7)

Safety Data

• Hazardous Substances Data: 16825-77-7(Hazardous Substances Data)

Upstream product

• 93-59-4 Perbenzoic acid 
• 67-66-3 chloroform 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 86532-26-5 <2-18F>Fluoronitrobenzene 

Relevant articles and documents

SYNTHESIS OF HYPERVALENT IODINE REAGENTS WITH DIOXYGEN

Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.

NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS

Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18] fluoride ion derived from anhydrous [F- 18]KF/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F- 18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.