1682653-80-0 Usage
Description
Tetrazine-PEG5-NHS Ester is a PEG linker containing a tetrazine group and an NHS ester, which is highly reactive with amine (NH2)-containing molecules. It features a hydrogen-substituted tetrazine that enables exceptionally fast click reactions with trans-cyclooctenes (TCO), generally at least 10-fold faster compared to methyl-substituted tetrazines. The aqueous solubility of this reagent is significantly enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
Uses
Used in Click Chemistry Applications:
Tetrazine-PEG5-NHS ester is used as a reactive component for the preparation of chitosan-polyacrylamide microspheres through selective tetrazine-trans-cyclooctene (Tz-TCO) ligation. This application takes advantage of the fast reaction kinetics between the tetrazine group and trans-cyclooctenes, allowing for efficient and specific ligation in the construction of these microspheres.
Used in Radiolabeling of Antibodies:
Tetrazine-PEG5-NHS ester is used as a labeling agent for the construction of copper-64 radiolabeled antibodies by the click reaction. The NHS ester group reacts with primary amines on the antibody, while the tetrazine group facilitates a rapid and efficient click reaction with trans-cyclooctenes, enabling the formation of stable radiolabeled antibody conjugates for various applications, such as imaging and targeted therapy.
Used in Pharmaceutical and Biomedical Research:
Tetrazine-PEG5-NHS ester is used as a versatile building block in the development of bioconjugates, drug delivery systems, and other biologically relevant molecules. The reactivity of the NHS ester with primary amines and the fast click reaction with TCO make it a valuable tool for creating novel bioactive compounds and materials with potential applications in drug discovery, diagnostics, and therapeutics.
Used in Material Science:
Tetrazine-PEG5-NHS ester can be employed as a key component in the synthesis of functional polymers and materials with specific properties, such as self-healing capabilities or stimuli-responsive behavior. The combination of the reactive NHS ester and the fast-clicking tetrazine group allows for the creation of complex polymer architectures and materials with tailored properties for various applications in material science and engineering.
Check Digit Verification of cas no
The CAS Registry Mumber 1682653-80-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,8,2,6,5 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1682653-80:
(9*1)+(8*6)+(7*8)+(6*2)+(5*6)+(4*5)+(3*3)+(2*8)+(1*0)=200
200 % 10 = 0
So 1682653-80-0 is a valid CAS Registry Number.