168286-97-3

Basic information

• Product Name: 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester
• Synonyms: 2-Oxo-2H-1-benzopyran-7-yl-β-D-glucopyranosiduronic Acid Methyl Ester Triacetate;7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester
• CAS NO: 168286-97-3
• Molecular Formula: C22H22O12
• Molecular Weight: 478.40288
• Product Categories: Glucuronides, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Glucuronides;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 168286-97-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 583.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester(168286-97-3)
• EPA Substance Registry System: 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester(168286-97-3)

Safety Data

• Hazardous Substances Data: 168286-97-3(Hazardous Substances Data)

Usage

Description

7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is a coumarin derivative characterized by its unique chemical structure, which includes a hydroxyl group, three acetyl groups, and a β-D-glucuronide methyl ester. 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is known for its potential applications in various fields, particularly in pharmaceutical and metabolic research.

Uses

Used in Pharmaceutical Industry:
7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is used as an intermediate compound for the preparation of Hydroxy Coumarin β-D-Glucuronide. This derivative serves as a valuable pharmacokinetic standard in metabolic studies, aiding in the understanding of drug metabolism and its effects on the human body.
Used in Metabolic Research:
In the field of metabolic research, 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester is utilized for the synthesis of Hydroxy Coumarin β-D-Glucuronide. 7-Hydroxy CouMarin 2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester acts as a pharmacokinetic standard, which is essential for evaluating the metabolic processes and the body's response to various drugs and substances. By using this standard, researchers can gain insights into the metabolic pathways and the efficiency of drug absorption, distribution, metabolism, and excretion.

Upstream product

• 186581-53-3 diazomethane 
• 108-24-7 acetic anhydride 
• 66695-14-5 7-Hydroxycoumarin glucuronide 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 92420-89-8 methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-D-glucopyranuronate 
• 72692-06-9 methyl 2,3,4-tri-O-acetyl-D-glucopyranuronate 

Downstream Products

• 66695-14-5 7-Hydroxycoumarin glucuronide 

Relevant articles and documents

Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide

A convenient synthesis of the important metabolite 7-hydroxycoumarin glucuronide 3 is presented, including a first report of the β-imidate 11β, together with new preparations of the iodosugar 6 and α-imidate 11α: stability data on 11α and 11β are also given, and the importance of carefully controlled hydrolysis in the last step of the preparation of 3 is emphasised.