16837-39-1

Basic information

• Product Name: pyridine-2-carboxylic anhydride
• Synonyms: pyridine-2-carboxylic anhydride;Bis(2-pyridinecarboxylic)anhydride;Einecs 240-861-1
• CAS NO: 16837-39-1
• Molecular Formula: C₁₂H₈N₂O₃
• Molecular Weight: 228.20352
• EINECS: 240-861-1
• Mol File: 16837-39-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 412.3°Cat760mmHg
• Flash Point: 203.1°C
• Appearance: /
• Density: 1.317g/cm³
• Vapor Pressure: 5.25E-07mmHg at 25°C
• Refractive Index: 1.599
• PKA: 0.42±0.10(Predicted)
• CAS DataBase Reference: pyridine-2-carboxylic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2-carboxylic anhydride(16837-39-1)
• EPA Substance Registry System: pyridine-2-carboxylic anhydride(16837-39-1)

Safety Data

• Hazardous Substances Data: 16837-39-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8N2O3/c15-11(9-5-1-3-7-13-9)17-12(16)10-6-2-4-8-14-10/h1-8H

Upstream product

• 98-98-6 2-Picolinic acid 

Relevant articles and documents

A versatile, practical, and inexpensive reagent, pyridine-3-carboxylic anhydride (3-PCA), for condensation reactions

A highly useful method for the preparation of carboxylic esters and carboxamides from various carboxylic acids was established by using a novel condensing reagent, pyridine-3-carboxylic anhydride (3-PCA), in the presence of 4-(dimethylamino)pyridine as an activator. The reactions of various carboxylic acids with nucleophiles, such as alcohols or amines, afforded the corresponding carboxylic acids or carboxamides in good to high yields under mild conditions by using simple experimental procedure. In addition, it was confirmed that this protocol was applicable to a gram-scale synthesis and the by-products, including pyridine-3-carboxylic acid and pyridine-3-carboxylate (or pyridine-3- carboxamide) produced in situ, were easily removed by using a simple aqueous workup.

A New Reagent for Activating Carboxy Groups; Preparation and Reactions of Phenyl N-Phenylphosphoramidochloridate

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