168426-25-3

Basic information

• Product Name: 3,5-bis(4-bromophenyl)pyridine
• Synonyms: 3,5-bis(4-bromophenyl)pyridine
• CAS NO: 168426-25-3
• Molecular Weight: 389.089
• Mol File: 168426-25-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3,5-bis(4-bromophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(4-bromophenyl)pyridine(168426-25-3)
• EPA Substance Registry System: 3,5-bis(4-bromophenyl)pyridine(168426-25-3)

Safety Data

• Hazardous Substances Data: 168426-25-3(Hazardous Substances Data)

Upstream product

• 72680-69-4 2--4'-bromostyrene 
• 10560-39-1 1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 55-21-0 benzamide 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 625-92-3 3,5-dibromopyridine 
• 5467-74-3 4-Bromophenylboronic acid 
• 53710-18-2 3,5-diiodopyridine 
• 54947-90-9 2-(4-bromophenyl)[1,3,2]dioxaborolane 
• 14091-15-7 p-bromo-DL-phenylalanine 

Downstream Products

• 168426-35-5 phenyl[1,1']pyridyl[4',1'']phenyl-4,4''-bis-carbonitrile 

Relevant articles and documents

Highly efficient one pot palladium-catalyzed synthesis of 3,5-bis (arylated) pyridines: Comparative experimental and DFT studies

Many different alkyl and aryl substituted pyridine based organic derivatives have been synthesized due to its uniqueness pyridine core. However, the transition metal catalyzed Suzuki cross coupling reaction has provided an easy route to the synthesis of a

Two C=C Bond Participation in Annulation to Pyridines Based on DMF as the Nonadjacent N and C Atom Donors

Two C=C bond participation in annulation to pyridines using N,N-dimethylformamide (DMF) as the N1 and C4 synthons has been carried out. In this reaction, DMF contributed one N atom and one C atom to two disconnected positions of pyridine ring, with no need for an additional nitrogen source. Two C=C bonds in two molecules of substituted styrenes offered four carbon atoms in the presence of iodine and persulfate. With the optimized conditions in hand, both symmetric and unsymmetric diaryl-substituted pyridines were obtained in useful yields. On the basis of relevant literature and a series of control experimental results, a possible mechanism was proposed in this work, which may demonstrate how DMF provides both N1 and C4 sources.

Insight into Copper Catalysis: In Situ Formed Nano Cu2O in Suzuki-Miyaura Cross-Coupling of Aryl/Indolyl Boronates

A ligand-free copper catalyzed Suzuki-Miyaura coupling of 3,5-diiodopyridine with aryl and indole boronates has been explored in good to excellent yields. In situ generation of nano-Cu2O from CuCl2 under the reaction conditions has been discovered for the first time. The generality of the reaction was further demonstrated by the arylation of 5-iodopyrimidine, iodopyridines, iodobenzenes, and diiodobenzenes and resulted in good to moderate yields. Moreover, bisindole alkaloid Scalaridine A has been successfully synthesized in 60% overall yield.