16850-00-3Relevant articles and documents
Poly-6-cationic amphiphilic cyclodextrins designed for gene delivery
Byrne, Colin,Sallas, Florence,Rai, Dilip K.,Ogier, Julien,Darcy, Raphael
, p. 3763 - 3771 (2009)
A new series of amphiphilic cyclodextrins containing cationic groups at the 6-positions and alkyl or biolabile ester groups at the 2-positions has been synthesised. Selective 2-O-allylation followed by photochemical addition of lipophilic thiols made it possible to control lipophilicity in these mesomolecules and allow solubility and self-assembly in water. The cationic groups are cysteamine-derived, while the alkyl and ester groups are C 1-C16 and benzyl ester groups. This is a new general synthetic route to a potentially wide range of polycationic cyclodextrins capable of acting as gene delivery vectors by condensing DNA and forming liquid crystalline complexes with oligonucleotides.
OXIME SULFONATE DERIVATIVES
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Page/Page column 56, (2016/03/22)
Oxime sulfonate compounds of the formula (I), wherein R 1 is O(CO)R 4, COOR 5 or CONR 6R 7; n is 1 or 2; R 2 for example is C 1-C 8alkyl, C 3-C 6
ORGANIC COMPOUNDS
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, (2008/06/13)
The present invention relates to compounds of the formula; and their use in therapy.
