1690-76-2

Basic information

• Product Name: 1,3-Dimethyl-piperidin-2-one
• Synonyms: 1,3-Dimethyl-piperidin-2-one
• CAS NO: 1690-76-2
• Molecular Formula: C7H13 N O
• Molecular Weight: 127.18
• Mol File: 1690-76-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 218.7°C at 760 mmHg
• Flash Point: 93.3°C
• Appearance: /
• Density: 0.949g/cm³
• Vapor Pressure: 0.124mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: 1,3-Dimethyl-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethyl-piperidin-2-one(1690-76-2)
• EPA Substance Registry System: 1,3-Dimethyl-piperidin-2-one(1690-76-2)

Safety Data

• Hazardous Substances Data: 1690-76-2(Hazardous Substances Data)

Usage

Abbreviation

DMP

Structure

Cyclic amide with a piperidin-2-one core and two methyl groups attached to the nitrogen atom

Solubility

Highly soluble in polar solvents

Applications

a. Building block in the synthesis of pharmaceuticals
b. Building block in the synthesis of agrochemicals
c. Building block in the synthesis of other fine chemicals
d. Reagent in organic synthesis
e. Precursor for the preparation of various derivatives

Chemical properties

Versatile, making it a valuable intermediate in the chemical industry

InChI:InChI=1/C7H13NO/c1-6-4-3-5-8(2)7(6)9/h6H,3-5H2,1-2H3

Upstream product

• 6456-92-4 1,3-dimethylpyridin-2(1H)-one 
• 1120-72-5 2-Methylcyclopentanone 
• 85462-16-4 N-Methyl-O-p-nitrophenylsulphonylhydroxylamine 
• 931-20-4 1-methylpiperidin-2-one 
• 917-54-4 methyllithium 
• 136788-07-3 trans-1,3-dimethyl-6-(methylthio)-2-piperidinone 
• 136788-07-3 cis-1,3-dimethyl-6-(methylthio)-2-piperidinone 
• 695-35-2 1,3-dimethylpiperidine 
• 136788-04-0 N,2-dimethyl-N-<1-(methylthio)ethenyl>-2-propenamide 
• 136788-05-1 N,2-dimethyl-N-<1-(phenylthio)ethenyl>-2-propenamide 
• 108-99-6 3-Methylpyridine 
• 3768-43-2 3-methyl-piperidin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 5631-71-0 1,5-dimethyl-1,2,3,4-tetrahydro-pyridine 
• 695-35-2 1,3-dimethylpiperidine 

Relevant articles and documents

EFFICIENT SYNTHESIS OF N-SUBSTITUTED LACTAMS FROM (N-ARYLSULFONYLOXY)AMINES AND CYCLIC KETONES

A new method is reported for the direct preparation of N-substituted lactams from cycloalkanones.N-(p-nitrobenzenesulfonoxyl) methylamine 1a (CH3NH-OSO2C6H4NO2) was reacted with a series of cycloalkanones to give good yields of N-methyl lactams.An addition-rearrangement pathway accounts for the ring-expanded lactam products.A series of N-alkyl-N-arylsulfonoxyl amines were generated in situ and reacted with cyclobutanone to give N-alkyl pyrrolidinones in high yields.

Utilizing Carbonyl Coordination of Native Amides for Palladium-Catalyzed C(sp3)?H Olefination

PdII-catalyzed C(sp3)?H olefination of weakly coordinating native amides is reported. Three major drawbacks of previous C(sp3)?H olefination protocols, 1) in situ cyclization of products, 2) incompatibility with α-H-containing substrates, and 3) installation of exogenous directing groups, are addressed by harnessing the carbonyl coordination ability of amides to direct C(sp3)?H activation. The method enables direct C(sp3)?H functionalization of a wide range of native amide substrates, including secondary, tertiary, and cyclic amides, for the first time. The utility of this process is demonstrated by diverse transformations of the olefination products.

PHOTOCYCLIZATION OF ENAMIDES. 38 REDUCTIVE PHOTOCYCLIZATION OF α-(METHYLTHIO)- AND α-(ARYLTHIO)ENAMIDES

Reductive photocyclization of α-(methylthio)enamide (2) gave exclusively six-membered lactams (3) and (4) while the same reaction of α-(arylthio)enamides (6) and (12) was found to afford five-membered lactams (7) and (13) as major products.A novel total s