169057-29-8

Basic information

• Product Name: (R)-1-(oxiran-2-yl)-2-phenylethanone
• Synonyms: (R)-1-(oxiran-2-yl)-2-phenylethanone
• CAS NO: 169057-29-8
• Molecular Weight: 162.188
• Mol File: 169057-29-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-1-(oxiran-2-yl)-2-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(oxiran-2-yl)-2-phenylethanone(169057-29-8)
• EPA Substance Registry System: (R)-1-(oxiran-2-yl)-2-phenylethanone(169057-29-8)

Safety Data

• Hazardous Substances Data: 169057-29-8(Hazardous Substances Data)

Upstream product

• 119373-39-6 1-benzylcyclopropan-1-ol 
• 4861-85-2 isopropyl phenylacetate 
• 122-78-1 phenylacetaldehyde 
• 6052-66-0 1-phenyl-3-buten-2-ol 
• 169302-18-5 (2S,3R)-3,4-epoxy-1-phenyl-2-butanol 
• 1589-82-8 phenylmagnesium bromide 
• 4538-50-5 methyl (2S)-glycidate 

Downstream Products

• 238753-83-8 [1-benzyl-2-(tert-butyl-dimethyl-silanyloxy)-pent-4-enyl]-methyl-carbamic acid tert-butyl ester 
• 238753-82-7 ((1S,2R)-1-Benzyl-2-methoxymethoxy-pent-4-enyl)-methyl-carbamic acid tert-butyl ester 
• 238753-81-6 Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 173204-72-3 (2S,3R)-2-[N-(t-butyloxycarbonyl)-N-methylamino]-1-phenylhex-5-en-3-ol 
• 238753-80-5 Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-amine 
• 157668-56-9 (4S,5R)-5-hydroxymethyl-4-phenylmethyloxazolidin-2-one 

Relevant articles and documents

An efficient route to α,β-epoxy ketones of high enantiomerical purity

Acylepoxides were obtained in high enantiomeric purity (ee = 92-99%) by addition of organolithium or Grignard reagents to enantiomerically pure methyl or ethyl 2,3-epoxypropanoates at low temperature (-85°C).

Total syntheses of kurasoins A and B, novel protein farnesyltransferase inhibitors, and absolute structures of kurasoins A and B

Asymmetric total syntheses of kurasoins A (1) and B (2), recently discovered protein farnesyltransferase (PFTase) inhibitors, have been achieved in seven steps from 2-(4-hydroxyphenyl)ethanol via the stereospecific alkylation of the chiral epoxide ((-)-7) and in four steps from phenylacetaldehyde via the coupling reaction of the chiral epoxide ((-)- 13) with indole, respectively. The synthesis defined the (3S) absolute configuration of 1 and 2. The stereochemistry of the hydroxy group is important for eliciting PFTase inhibition.