16908-91-1Relevant articles and documents
Synthesis method and application of isosorbide mononitrate
-
Paragraph 0032-0040, (2021/07/14)
The invention belongs to the field of medicine synthesis, and discloses a synthesis method and application of isosorbide mononitrate. The synthesis method of the isosorbide mononitrate provided by the invention adopts a one-pot method and comprises the following steps: adding sorbitol into concentrated sulfuric acid, dehydrating and cyclizing, adding nitrate, carrying out nitration reaction, and adding zinc powder to carry out reduction reaction, thereby obtaining the isosorbide mononitrate. The synthesis method has the advantages of simple process flow, high raw material utilization rate and production cost saving. The method is suitable for synthesizing the isosorbide mononitrate, and the obtained isosorbide mononitrate is used for preparing the isosorbide mononitrate for injection.
A 5 - isosorbide Mononitrate preparation method (by machine translation)
-
Paragraph 0020; 0037-0052, (2019/11/14)
The present invention provides a 5 - isosorbide Mononitrate synthetic method. The method includes the steps of: in order to isosorbide as raw materials, with the nitrates TMSCl nitrating agent in three of the aluminum chloride under the action of selective nitration sorbitan 5 - hydroxyl, completion of the reaction, the reaction liquid is poured into ice water, adjusting the pH value to neutral, filtering precipitation, phase separation, the aqueous phase of the liquid organic solvent extraction, the organic phase into the drying agent and, decolorized with active carbon, concentrated under reduced pressure to dry, to obtain high-purity of 5 - isosorbide Mononitrate. The scheme of this invention mild reaction conditions, nitration high selectivity, after treatment is simple, high product yield and purity, is suitable for industrial production. (by machine translation)
Method for synthesizing 5-isosorbide mononitrate by aid of micro-channel reactors
-
Paragraph 0048-0078; 0095; 0097, (2018/10/19)
The invention belongs to the field of medicine synthesis, and particularly discloses a method for synthesizing 5-isosorbide mononitrate by the aid of micro-channel reactors. The method includes pumping nitrification reagents and isosorbide liquid into the micro-channel reactors and carrying out hybrid reaction; allowing products to flow out from outlets of the micro-channel reactors after the reaction is completely carried out; carrying out after-treatment on the products and separating and purifying the products to obtain the 5-isosorbide mononitrate which is a target product. The method hasthe advantages that the method is short in reaction time and is safe as compared with the traditional processes, and the yield of the 5-isosorbide mononitrate can be greatly increased.