1691250-97-1

Basic information

• Product Name: tert-butyl (2R,4R)-4-amino-2-methylpiperidine-1-carboxylate
• CAS NO: 1691250-97-1
• Molecular Weight: 214.308
• Mol File: 1691250-97-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl (2R,4R)-4-amino-2-methylpiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R,4R)-4-amino-2-methylpiperidine-1-carboxylate(1691250-97-1)
• EPA Substance Registry System: tert-butyl (2R,4R)-4-amino-2-methylpiperidine-1-carboxylate(1691250-97-1)

Safety Data

• Hazardous Substances Data: 1691250-97-1(Hazardous Substances Data)

Upstream product

• 790667-43-5 (2R)-2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 790667-49-1 (S)-2-methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 790667-91-3 (2S,4R)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate 
• 190906-92-4 tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate 

Downstream Products

• 2409589-97-3 benzyl (2S)-2-methylpiperidin-4-yl-carbamate 

Relevant articles and documents

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3- b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors

Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of current JAK inhibitors to JAK isoforms allowed the design of N-alkyl-substituted 1-H-pyrrolo[2,3-b] pyridine carboxamide as a JAK1-selective scaffold, and the synthesis of various methyl amide derivatives provided 4-((cis-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (31g) as a potent JAK1-selective inhibitor. In particular, the (S,S)-enantiomer of 31g (38a) exhibited excellent potency for JAK1 and selectivity over JAK2, JAK3, and TYK2. On investigating the effect of 31g on hepatic fibrosis, it was found that it reduces the proliferation and fibrogenic gene expression of TGF-β-induced hepatic stellate cells (HSCs). Specifically, 31g significantly inhibited TGF-β-induced migration of HSCs at 0.25 μM in wound-healing assays.

SUBSTITUTED PIPERIDINE COMPOUNDS

The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure i

TRPA1 MODULATORS

This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the compounds.