169218-36-4Relevant articles and documents
Tacilol isomer impurity PY3 and preparation method and use thereof
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, (2018/07/07)
The present invention discloses a tacilol isomer impurity PY3 and a preparation method thereof, and belongs to the chemical pharmaceutical technical field. The tacilol isomer impurity PY3 is (1beta, 3beta, 5Z, 7E, 22E)-9,10-secoergosta-5, 7, 10 (19), 22-tetraen-1,3-diol. The high-purity alfacalcidol-related impurity PY3 can be used as an impurity standard in the detection and analysis of an alfacalcidol finished product, accurate positioning and characterization of impurities in the detection and analysis of the alfacalcidol finished product can be promoted, enhancement of control of the impurities can be facilitated, and the quality of the alfacalcidol finished product can be improved. The method has the advantages of low cost and easy availability of raw materials, simple operation and good reproducibility, and the HPLC purity is >=99.5%.