1693-28-3

Basic information

• Product Name: 2-Trifluoromethyl thioxanthone
• Synonyms: 2-Trifludromethylthioxanthone;2-TRIFLUOROMETHYL-10-THIAXANTHEN-9-ONE;2-TRIFLUOROMETHYL-9H-THIOXANTHEN-9-ONE;2-TRIFLUORO METHYL-9H-THIOXANTHONE;2-TRIFLUOROMETHYL-9-THIOXANTHONE;2-(TRIFLUOROMETHYL)THIOXANTHEN-9-ONE;2-TRIFLUOROMETHYLTHIOXANTHONE;9H-THIOXANTHEN-9-ONE, 2-(TRIFLUOROMETHYL)-
• CAS NO: 1693-28-3
• Molecular Formula: C₁₄H₇F₃OS
• Molecular Weight: 280.26
• EINECS: 216-893-7
• Product Categories: Sulphur Derivatives;Heterocyclic Building Blocks;Others;S-Containing;Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1693-28-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 147-151 °C(lit.)
• Boiling Point: 375.1 °C at 760 mmHg
• Flash Point: 180.7 °C
• Appearance: Pale yellow/Crystalline
• Density: 1.433 g/cm³
• Vapor Pressure: 7.97E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Trifluoromethyl thioxanthone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Trifluoromethyl thioxanthone(1693-28-3)
• EPA Substance Registry System: 2-Trifluoromethyl thioxanthone(1693-28-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1693-28-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

2-Trifluoromethylthioxanthone is a decomposition product of the dopamine receptor antagonist and antipsychotic agent Flupentixol (F598050).

InChI:InChI=1/C14H7F3OS/c15-14(16,17)8-5-6-12-10(7-8)13(18)9-3-1-2-4-11(9)19-12/h1-7H

Upstream product

• 83986-19-0 [2-(2-Fluoro-phenylsulfanyl)-5-trifluoromethyl-phenyl]-(1-methyl-piperidin-4-yl)-methanol 
• 2557-78-0 2-fluorothiophenol 
• 82386-89-8 2-chloro-5-(trifluoromethyl)benzaldehyde 
• 83986-21-4 2-(2-Fluorophenylthio)-5-trifluoromethylbenzaldehyde 
• 2413-38-9 (Z)-Flupentixol dihydrochloride 
• 729-10-2 2-(trifluoromethyl)-9H-thioxanthene 

Downstream Products

• 51395-46-1 1-methyl-4-(2-trifluoromethyl-thioxanthen-9-ylidene)-piperidine 

Relevant articles and documents

Ultraviolet-light-induced aerobic oxidation of benzylic C(sp3)-H of alkylarenes under catalyst- and additive-free conditions

A mild and efficient system has been discovered for the synthesis of α-aryl carbonyl compounds via oxidation of benzylic C–H to C[dbnd]O bonds. This ultraviolet-light-mediated oxygenation reaction exhibited excellent substrate scope including various xanthenes, thioxanthenes and 9, 10-dihydroacridines and afforded the corresponding ketones with good to excellent yields under catalyst- and additive-free conditions at room temperature.

Visible-Light-Induced Aerobic Oxidation of Benzylic C(sp 3)-H of Alkylarenes Promoted by DDQ, tert -Butyl Nitrite, and Acetic Acid

A visible-light photocatalytic aerobic oxidation of benzylic C(sp 3)-H bonds proceeded in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, tert -butyl nitrite, and acetic acid. Advantages of this aerobic oxidation method include its relatively mild conditions, the use of visible-light irradiation instead of conventional thermal methods, the use of a low catalyst loading, and the ability to oxidize a range of alkylarenes, including xanthenes, thioxanthenes, and 9,10-dihydroacridines, to the corresponding ketones in excellent yields.

Method for catalytic oxidization synthesis of anthone compound

The invention discloses a method for catalytic oxidation synthesis of an anthone compound. The method is carried out according to the following steps: adding an anthene compound, Fe(NO3)3*9H2O and a fluorine-containing inorganic salt into an acetonitrile solvent, and performing a reaction for 2-12h at 75-85 DEG C under a normal pressure oxygen condition to obtain the anthone compound, wherein the mass ratio of the reaction substrate namely the anthone compound, Fe(NO3)3*9H2O and the fluorine-containing inorganic salt is 100:(8-15):(15-30), and after the completion of the reaction, the anthone compound can be obtained by adopting conventional column separation purification. The method provided by the invention is simple, convenient and safe to operate, and has the following beneficial effects: A) clean oxygen is used as an oxidant in the method, so that the environmental cost is greatly reduced; and B) Fe(NO3)3*9H2O is used as a catalyst in the method, so that the cost is low.