16934-08-0Relevant articles and documents
Effect of Microwave Irradiation on the Catalytic Activity of Palladium Supported Catalysts in the One-Step Isomerisation of Cinchona Alkaloids to Δ3,10-Isobases
Lipińska, Teodozja M.,Borowska, Dominika,Sw?dra, Natalia,Trochim, Katarzyna
, p. 2835 - 2843 (2017)
Abstract: Efficiency of palladium solid supported (Pd/SS) catalysts for one-step isomerisation of the side chain of four natural Cinchona alkaloids have been explored under controlled microwave heating in the green media (50% aqueous ethanol or ethylene g
Positional isomerization of quinine and quinidine via rhodium on alumina catalysis: Practical one-step synthesis of Δ3,10-isoquinine and Δ3,10-isoquinidine
Portlock, David E.,Naskar, Dinabandhu,West, Laura,Seibel, William L.,Gu, Titan,Krauss, Howard J.,Peng, X. Sean,Dybas, Paul M.,Soyke, Edward G.,Ashton, Stephen B.,Burton, Jonathan
, p. 5365 - 5368 (2007/10/03)
The synthesis of Δ3,10-isoquinine (5Z,5E) and Δ3,10-isoquinidine (6Z,6E) was achieved in one-step through positional isomerization of the terminal alkene in the parent cinchona alkaloids using catalytic amounts of 5% Rh/Al2O3 and excess hydrochloric acid in refluxing 50% aqueous EtOH. The products were obtained in good yields as a mixture of E and Z geometric isomers and fully characterized using spectroscopic methods.
