169471-41-4 Usage
Description
1,3-BispalMitoyl-2-chloropropanediol, also known as 1,3-Dipalmitoyl-2-chloropropanediol, is an off-white to pale yellow solid with unique chemical properties. It is a synthetic compound that has found applications in various industries due to its specific characteristics.
Uses
Used in Pharmaceutical Industry:
1,3-BispalMitoyl-2-chloropropanediol is used as a synthetic intermediate for the development of prodrugs, specifically for Piroxicam and Lornoxicam. The application reason is to enhance their bioavailability, making the drugs more effective and better absorbed by the body.
Used in Chemical Synthesis:
1,3-BispalMitoyl-2-chloropropanediol is used as a key component in the synthesis of various chemical compounds, taking advantage of its unique chemical properties to create new molecules with specific applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 169471-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,4,7 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 169471-41:
(8*1)+(7*6)+(6*9)+(5*4)+(4*7)+(3*1)+(2*4)+(1*1)=164
164 % 10 = 4
So 169471-41-4 is a valid CAS Registry Number.
169471-41-4Relevant articles and documents
Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice
Zhang, Zhongfei,Yang, Puyu,Gao, Boyan,Huang, Guoren,Liu, Man,Yu, Liangli Lucy
, p. 3789 - 3795 (2019/04/10)
A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH4 and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. In addition, 2-MCPD monopalmitate and dipalmitate were examined for their acute oral toxicities in Swiss mice. The LD50 values of 2-MCPD mono- and dipalmitate were greater than 5000 mg/kg body weight (BW), along with detectable nephrotoxicity and testicular toxicity. The results of this study may promote future investigation of MCPD ester toxicology and detection.
