169515-32-6Relevant articles and documents
Synthesis of 3',5'-dithymidylyl-α-hydroxyphosphonate dimer building blocks for oligonucleotide synthesis - A new pro-oligonucleotide approach
Mauritz, Ralf P.,Meier, Chris,Uhlmann, Eugen
, p. 1209 - 1212 (1997)
The synthesis of the dimer building blocks 1 and 2 and their introduction into (T)15-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T(m) values) were examined.
Solution-phase synthesis of phosphorothioate oligonucleotides using a solid-supported acyl chloride with H-phosphonate chemistry
Adamo, Ilaria,Dueymes, Cecile,Schoenberger, Andreas,Navarro, Aude-Emmanuelle,Meyer, Albert,Lange, Meinolf,Imbach, Jean-Louis,Link, Fritz,Morvan, Francois,Vasseur, Jean-Jacques
, p. 436 - 448 (2007/10/03)
The synthesis of oligonucleotides from dimers to a hexamer by a H-phosphonate approach in solution using solid-supported acyl chloride is reported herein. This strategy avoids the use of chromatography. The work-ups have been simplified and involve filtra
Synthesis of protected 3',5'-di-2'-deoxythymidine-(α-hydroxy-2- nitrobenzyl)-phosphonate diesters as dimer building blocks for oligonucleotides
Meier,Mauritz
, p. 803 - 804 (2007/10/02)
The synthesis of 3'-succinyl-CPG bound 3',5'-di-2'-deoxythymidyl-(α- hydroxy-2-nitrobenzyl)-phosphonate diester 1 and the 3'-phosphoamidite derivative 2 is described. The hydroxyl-groups of the backbone modification were protected with trialkylsilyl group
