169701-72-8

Basic information

• Product Name: (3S)-3-(tert-butoxycarbonylamino)-4-methyl-1-(phenylsulfonyl)-2-pentanone
• Synonyms: (3S)-3-(tert-butoxycarbonylamino)-4-methyl-1-(phenylsulfonyl)-2-pentanone
• CAS NO: 169701-72-8
• Molecular Weight: 355.455
• Mol File: 169701-72-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S)-3-(tert-butoxycarbonylamino)-4-methyl-1-(phenylsulfonyl)-2-pentanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3-(tert-butoxycarbonylamino)-4-methyl-1-(phenylsulfonyl)-2-pentanone(169701-72-8)
• EPA Substance Registry System: (3S)-3-(tert-butoxycarbonylamino)-4-methyl-1-(phenylsulfonyl)-2-pentanone(169701-72-8)

Safety Data

• Hazardous Substances Data: 169701-72-8(Hazardous Substances Data)

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 

Relevant articles and documents

Synthesis of chiral, enantiopure allylic amines by the Julia olefination of α-amino esters

The four-step conversion of a series of N-Boc-protected L-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of α-amino aldehydes.