169758-66-1

Basic information

• Product Name: Robalzotan
• Synonyms: Robalzotan;Robalzotan [inn];Unii-I18m56ogme;(3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamidehydrochloride;NAD 299;(R)-3-(DicyclobutylaMino)-8-fluorochroMan-5-carboxaMide;NAD 299 hydrochloride (Robalzotan);NAD 299 hydrochloride
• CAS NO: 169758-66-1
• Molecular Formula: C18H23FN2O2.C4H6O6.H2O
• Molecular Weight: 486.49
• Mol File: 169758-66-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 429.9°C at 760 mmHg
• Flash Point: 213.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 1.36E-07mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Desiccate at RT
• PKA: 15.72±0.40(Predicted)
• CAS DataBase Reference: Robalzotan(CAS DataBase Reference)
• NIST Chemistry Reference: Robalzotan(169758-66-1)
• EPA Substance Registry System: Robalzotan(169758-66-1)

Safety Data

• Hazardous Substances Data: 169758-66-1(Hazardous Substances Data)

Usage

Description

Robalzotan is a compound with specific properties that make it suitable for various applications across different industries. It is characterized by its unique chemical structure and functional groups that allow it to interact with other molecules and systems.

Uses

Used in Psychotropic Drug Development:
Robalzotan is used as a selective, high affinity 5-HT1A antagonist for the development of psychotropic drugs. Its ability to modulate serotonin receptors plays a crucial role in addressing various psychiatric and neurological conditions.
If there are additional applications in different industries, they can be listed as follows:
Used in [Application Industry]:
Robalzotan is used as [application type] for [application reason].
Please provide more information or context about the specific applications and industries for Robalzotan, and I can help you organize the description and uses accordingly.

Biological Activity

Selective, high affinity 5-HT 1A receptor antagonist (K i = 0.6 nM in vitro ).

InChI:InChI=1/C18H23FN2O2/c19-16-8-7-14(18(20)22)15-9-13(10-23-17(15)16)21(11-3-1-4-11)12-5-2-6-12/h7-8,11-13H,1-6,9-10H2,(H2,20,22)/t13-/m1/s1

Upstream product

• 169759-10-8 methyl (R)-3-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxylate 
• 214823-10-6 (R)-(+)-3-amino-8-fluorochromane-5-carboxamide 
• 1191-95-3 cyclobutanone 

Relevant articles and documents

Process for the manufacture of 3-N-N-dicyclobutylamino-8-fluoro-3, 4-dihydro-2H-1-benzopyran-5-carboxamide

A process for the manufacture of the racemic compound of the formula (I), its R-enantiomer (formula R-(I)) and its S-enantiomer (formula S-(I)), and pharmaceutically acceptable salts and/or solvates thereof, as well as new intermediates obtained and used in the process.

USE OF 5-HT1A RECEPTOR ANTAGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE

The present invention discloses compositions and methods for treating neuromuscular dysfunction of the lower urinary tract in mammals, including humans, using serotonin 5-HT 1A receptor antagonist compounds that exert their inhibitory effects via pre-syna