1699-38-3

Basic information

• Product Name: 2-BENZYLOXY-4-CHLOROMETHYL-1-METHOXYBENZENE
• Synonyms: 2-BENZYLOXY-4-CHLOROMETHYL-1-METHOXYBENZENE;4-(chloromethyl)-1-methoxy-2-phenylmethoxybenzene
• CAS NO: 1699-38-3
• Molecular Formula: C₁₅H₁₅ClO₂
• Molecular Weight: 262.7314
• Mol File: 1699-38-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 380.8°Cat760mmHg
• Flash Point: 141.5°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-BENZYLOXY-4-CHLOROMETHYL-1-METHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYLOXY-4-CHLOROMETHYL-1-METHOXYBENZENE(1699-38-3)
• EPA Substance Registry System: 2-BENZYLOXY-4-CHLOROMETHYL-1-METHOXYBENZENE(1699-38-3)

Safety Data

• Hazardous Substances Data: 1699-38-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H15ClO2/c1-17-14-8-7-13(10-16)9-15(14)18-11-12-5-3-2-4-6-12/h2-9H,10-11H2,1H3

Upstream product

• 1860-60-2 3-benzyloxy-4-methoxy-benzyl alcohol 
• 621-59-0 isovanillin 
• 100-39-0 benzyl bromide 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 4383-06-6 3-hydroxy-4-methoxybenzyl alcohol 

Downstream Products

• 1699-39-4 2-(3-(benzyloxy)-4-methoxyphenyl)acetonitrile 
• 57535-60-1 3-Benzyloxy-4-methoxybenzylazid 
• 38750-42-4 6-benzoyl-5-(3-benzyloxy-4-methoxy-benzyl)-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 81782-24-3 N-(3-benzyloxy-4-methoxybenzyl)aziridine 
• 6527-13-5 3,4-dimethoxy-(phenylmethoxy)benzaldehyde 
• 106345-53-3 3-benzyloxy-4-methoxybenzyl 3,4-dimethoxyphenyl ketone 
• 94707-57-0 N-<1,2-bis<3-(benzyloxy)-4-methoxyphenyl>ethyl>-N-methylamine 
• 82958-03-0 6-Benzoyl-5-(3-benzyloxy-4-methoxy-benzyl)-4-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonitrile 
• 142050-37-1 3-benzyloxy-4-methoxybenzyl <14C>cyanide 
• 76799-34-3 N-<3-(benzyloxy)-4-methoxybenzyl>-2,4,6-tris(benzyloxy)benzamide 
• 77564-69-3 2-Benzyl-5,7-bis-benzyloxy-1-(3-benzyloxy-4-methoxy-benzyl)-1,2-dihydro-isoquinoline 
• 38750-43-5 O-benzylisosevanine 
• 258270-07-4 3-(3-hydroxy-4-methoxy)phenyl-8H-thieno[2,3-b]pyrrolizin-8-one 
• 373392-95-1 methyl 3-amino-4-(3-benzyloxy-4-methoxyphenyl)-2-thiophene carboxylate 

Relevant articles and documents

PHENANTHROINDOLIZIDINE AND PHENANTHROQUINOLIZIDINE ALKALOID HAVING A HYDROXYL GROUP ON THE PHENANTHRENE RING THEREOF, PREPARATION METHOD AND USE THEREOF

A phenanthroindolizidine and phenanthroquinolizidine alkaloid having a hydroxyl group on the phenanthrene ring thereof was synthesized, which exhibits potent activity as an anticancer agent against, such as breast cancer, lung cancer, and prostate cancer.

Facile and Divergent Synthesis of Lamellarins and Lactam-Containing Derivatives with Improved Drug Likeness and Biological Activities

With the goal to improve the aqueous solubility of lamellarins, the lactone ring in their skeleton was replaced with a lactam moiety in azalamellarins. However, the reported synthetic route produced such derivatives in very low yields. Hence, this study focused on developing an efficient simplified total synthetic scheme that could furnish both azalamellarins and the parent lamellarins from the same pyrrole ester intermediates. Subsequent comparative profiling revealed that the introduced lactone-to-lactam replacement rendered these molecules less lipophilic, whereas their cancer cytotoxicity remained equipotent to that of the parent compounds. Interestingly, their inhibitory activity was significantly enhanced towards the multifaceted GSK-3β enzyme. Our results clearly demonstrate the therapeutic potential of this promising class of marine-derived natural products and justify their further development, especially into anticancer agents.

NOVEL HYPOXANTHINE AND THIOHYPOXANTHINE COMPOUNDS

Disclosed are compounds of formula (I) wherein R3, R6, R8 are as described herein. The compounds are effective selective PDE IV inhibitors.