1699-56-5

Basic information

• Product Name: 3,4-Dibenzyloxyphenethylamine hydrochloride
• Synonyms: 3,4-(DIBENZYLOXY)PHENETHYLAMINE HYDROCHLORIDE;3,4-bis(benzyloxy)phenethylamine hydrochloride;3,4-DibenzyloxyphenethylamineHCl;3,4-Dibenzyloxyphenethylamine hydrochloride, HPLC 98%;3,4-DIBENZYLOXYPHENETHYLAMINE HYDROCHLORIDE 98%;(4-CHLORO-3-NITROPHENYL)(CYCLOPROPYL)METHANONE;3,4-(Dibenzyloxy)phenethylamine hydrochloride,98%;(4-Chloro-3-Nitrophenyl)(cy
• CAS NO: 1699-56-5
• Molecular Formula: C₂₂H₂₃NO₂*ClH
• Molecular Weight: 369.88
• EINECS: 216-924-4
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks;Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;CMLLYL
• Mol File: 1699-56-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 131-133 °C(lit.)
• Boiling Point: 493.4 °C at 760 mmHg
• Flash Point: 279.8 °C
• Appearance: beige powder
• Vapor Pressure: 7.05E-10mmHg at 25°C
• CAS DataBase Reference: 3,4-Dibenzyloxyphenethylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dibenzyloxyphenethylamine hydrochloride(1699-56-5)
• EPA Substance Registry System: 3,4-Dibenzyloxyphenethylamine hydrochloride(1699-56-5)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-37/38-41-50/53
• Safety Statements: 24/25-61-60-39-26
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1699-56-5(Hazardous Substances Data)

Usage

Description

3,4-Dibenzyloxyphenethylamine hydrochloride is an organic compound with the chemical formula C20H23NO2·HCl. It is a beige powder and is commonly used as a reagent in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Synthesis:
3,4-Dibenzyloxyphenethylamine hydrochloride is used as a reagent for the synthesis of tetrahydroisoquinoline derivatives containing 4(hexylureido)benzenesulfonamide, which act as human β3 adrenergic receptor agonists. These agonists have potential applications in the treatment of various medical conditions, such as obesity and type 2 diabetes.
Additionally, 3,4-Dibenzyloxyphenethylamine hydrochloride is used as a reagent in the synthesis of prodrugs of dopamine. Dopamine prodrugs are compounds that can be converted into dopamine in the body, which may have potential therapeutic applications in treating conditions related to dopamine deficiency, such as Parkinson's disease.

InChI:InChI=1/C22H23NO2/c23-14-13-18-11-12-21(24-16-19-7-3-1-4-8-19)22(15-18)25-17-20-9-5-2-6-10-20/h1-12,15H,13-14,16-17,23H2/p+1

Upstream product

• 1699-54-3 3,4-bis(benzyloxy)-β-nitrostyrene 
• 300362-80-5 N-tert-butoxycarbonyl-3,4-dibenzyloxyphenylethylamine 
• 51-61-6 dopamine 
• 37034-31-4 N-(tert-butoxycarbonyl)dopamine 
• 100-39-0 benzyl bromide 

Downstream Products

• 82741-47-7 N-isonicotinoyl-3,4-(dibenzyloxy)phenethylamine 
• 81861-36-1 [2-(3,4-Bis-benzyloxy-phenyl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-amine; hydrochloride 
• 23428-48-0 N-(3,4-dibenzyloxyphenethyl)-4-benzyloxyphenylacetamide 
• 144226-18-6 N-<3,4-bis(benzyloxy)phenethyl>-N^α,N^δ-bis(benzyloxycarbonyl)-N^α-<3-<(benzyloxycarbonyl)amino>propyl>-L-ornithinate 
• 816429-78-4 N-[2-(3,4-bis-benzyloxy-phenyl)-ethyl]-succinamic acid methyl ester 
• 300362-70-3 3-(3,4-bis(benzyloxy)phenethylcarbamoyl) propanoic acid 
• 314068-11-6 N-[6-(6,7-bis-benzyloxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethoxy)-naphthalen-2-yl]-4-(3-hexyl-ureido)-benzenesulfonamide 
• 241467-61-8 N-[2-(3,4-bis-benzyloxy-phenyl)-ethyl]-2-{6-[4-(3-hexyl-ureido)-benzenesulfonylamino]-naphthalen-2-yloxy}-acetamide 
• 81861-37-2 4-<2-<<2-(3,4-dihydroxyphenyl)-1-methylethyl>amino>ethyl>-1,2-dimethoxybenzene 
• 79831-99-5 NN-bis-(3,4-dihydroxyphenethyl)amine hydrochloride 
• 3184-36-9 norlaudanosoline hydrochloride 
• 79832-00-1 6,7-dihydroxy-1-(4-hydroxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 11041-94-4 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 54781-85-0 6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-3,4-dihydroisoquinoline hydrochloride 

Relevant articles and documents

Metal-assisted assembly and stabilization of collagen-like triple helices

Single-chain and TRIS-assembled collagen mimetic peptide structures incorporating catechol groups were synthesized. When 1/3 equiv of Fe3+ was added to the single-chain compound in 50 mM CAPS buffer (pH 10), the 1:3 Fe3+-catechol complex that formed acted as an N-terminal scaffold to assemble the triple helix. When 1 equiv of Fe3+ was added to the TRIS-assembled compound in the buffer solution, the Fe3+-catechol complex acted as an extra C-terminal scaffold, which lead to a triple helix with both termini tethered. The formation of this C-terminal complex increased the Tm by a remarkable 22 °C! Copyright