1699-62-3

Basic information

• Product Name: N-(3,4-bis(benzyloxy)phenethyl)-2-(3,4-bis(benzyloxy)phenyl)acetamide
• Synonyms: N-(3,4-bis(benzyloxy)phenethyl)-2-(3,4-bis(benzyloxy)phenyl)acetamide
• CAS NO: 1699-62-3
• Molecular Weight: 663.813
• Mol File: 1699-62-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3,4-bis(benzyloxy)phenethyl)-2-(3,4-bis(benzyloxy)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-bis(benzyloxy)phenethyl)-2-(3,4-bis(benzyloxy)phenyl)acetamide(1699-62-3)
• EPA Substance Registry System: N-(3,4-bis(benzyloxy)phenethyl)-2-(3,4-bis(benzyloxy)phenyl)acetamide(1699-62-3)

Safety Data

• Hazardous Substances Data: 1699-62-3(Hazardous Substances Data)

Upstream product

• 1699-61-2 <3,4-bis(benzyloxy)phenyl>acetic acid 
• 55536-65-7 3,4-di(benzyloxy)phenethylamine 
• 100-39-0 benzyl bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1699-54-3 (E)-3,4-dibenzyloxy-β-nitrostyrene 
• 1699-59-8 3,4-dibenzyloxybenzyl chloride 
• 1699-58-7 3,4-bis(benzyloxy)benzyl alcohol 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1699-60-1 (3,4-bis-benzyloxyphenyl)acetonitrile 
• 1699-54-3 3,4-bis(benzyloxy)-β-nitrostyrene 

Downstream Products

• 79831-99-5 NN-bis-(3,4-dihydroxyphenethyl)amine hydrochloride 
• 3184-36-9 norlaudanosoline hydrochloride 
• 54781-85-0 6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 79832-14-7 6,7-bisbenzyloxy-1-(3,4-bisbenzyloxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 79831-95-1 NN-bis-(3,4-dibenzyloxyphenethyl)amine hydrochloride 
• 1932-43-0 6,7-bisbenzyloxy-1-(3,4-bisbenzyloxybenzyl)-3,4-dihydroisoquinoline hydrochloride 

Relevant articles and documents

Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease

Currently, influenza PAN endonuclease has become an attractive target for development of new drugs to treat influenza infections. Herein we report the discovery of new PAN endonuclease inhibitors derived from a chelating agent dopamine moiety. A series of dopamine amide derivatives and their conformationally constrained 1,2,3,4-tetrahydroisoquinoline-6,7-diol-based analogs were elaborated and assayed against influenza virus A/WSN/33 (H1N1). Most compounds exhibited moderate to excellent antiviral activities, generating a preliminary SARs. Among them, compounds 14 and 19 showed stronger anti-IAV activity compared with the reference Peramivir. Moreover, 14 and 19 demonstrated a concentration-dependent inhibition of PAN endonuclease based on both FRET assay and SPR assay. Docking studies were also performed to elucidate the binding mode of 14 and 19 with the PAN protein and to identify amino acids involved in their mechanism of action, which were well consistent with the biological data. This finding was beneficial to laying the foundation for the rational development of more effective PAN endonuclease inhibitors.