16992-51-1Relevant articles and documents
New synthesis of estradiol from androsta-1,4-diene-3,17-dione
Vasiljeva,Demin,Kochev,Lapitskaya,Pivnitsky
, p. 593 - 595 (1999)
A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.