1701-19-5

Basic information

• Product Name: 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 8-METHYL-2-(TRIFLUOROMETHYL)4-QUINOLINOL;8-METHYL-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL;4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE;BUTTPARK 95\04-21;4-Hydroxy-8-methyl-2-(trifluoromethyl)quinoline 97%;4-Hydroxy-8-methyl-2-(trifluoromethyl)quinoline97%
• CAS NO: 1701-19-5
• Molecular Formula: C11H8F3NO
• Molecular Weight: 227.18
• Mol File: 1701-19-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-131°C
• Boiling Point: 245.6 °C at 760 mmHg
• Flash Point: 102.4 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 0.0284mmHg at 25°C
• Refractive Index: 1.515
• PKA: 6.80±0.40(Predicted)
• CAS DataBase Reference: 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE(1701-19-5)
• EPA Substance Registry System: 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE(1701-19-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 1701-19-5(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE is a chemical compound with a quinoline structure and a hydroxyl group and a methyl group attached to it. Additionally, a trifluoromethyl group is also present in the compound. It is used in various chemical and pharmaceutical applications, including as a building block for the synthesis of other compounds and as a reagent in organic chemistry reactions. The trifluoromethyl group also imparts unique and useful properties to the compound, making it valuable in certain applications. Overall, 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE is a versatile and important chemical compound with a range of potential uses.

InChI:InChI=1/C11H8F3NO/c1-6-3-2-4-7-8(16)5-9(11(12,13)14)15-10(6)7/h2-5H,1H3,(H,15,16)

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 95-53-4 o-toluidine 

Downstream Products

• 1701-25-3 4-chloro-8-methyl-2-trifluoromethyl-quinoline 

Relevant articles and documents

Investigations into the flexibility of the 3D structure and rigid backbone of quinoline by fluorine addition to enhance its blue emission

Achieving the desired structures of organic molecules for targeted applications is vital. Folding caused by weak intermolecular forces plays an important part in their 3D structure. Powerful tools which enable us to do this are currently under investigation by researchers across the globe. On this account, quinoline was chosen as a model scaffold because of its rigid 3D structure. Addition of fluorine was found to result in increased flexibility of the structure with a decrease in the number of intermolecular interactions. This resulted in improvement of their photophysics and blue emission. A total of 19 novel fluoroquinoline molecules were synthesised in order to carry out this study. Of these, grown crystals of 10 compounds were successfully achieved and used. In addition, characterisation techniques such as NMR, HRMS, UV-vis and computational techniques were used to explore the 3D structure of these molecules.

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.