170152-21-3

Basic information

• Product Name: ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate
• Synonyms: ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate
• CAS NO: 170152-21-3
• Molecular Weight: 428.463
• Mol File: 170152-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate(170152-21-3)
• EPA Substance Registry System: ethyl 8-(4-fluorobenzoyl)-4-(o-tolylamino)quinoline-3-carboxylate(170152-21-3)

Safety Data

• Hazardous Substances Data: 170152-21-3(Hazardous Substances Data)

Upstream product

• 455889-15-3 3-ethyl 8-methyl 4-(o-tolylamino)quinoline-3,8-dicarboxylate 
• 1765-93-1 4-fluoroboronic acid 
• 1235283-75-6 3-ethyl 8-methyl 4-chloroquinoline-3,8-dicarboxylate 
• 111185-66-1 3-ethyl-8-methyl-4-oxo-1,4-dihydroquinoline-3,8-dicarboxylate 
• 42063-41-2 2-[(2-methoxycarbonylphenylamino)methylene]malonic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 134-20-3 2-carbomethoxyaniline 

Relevant articles and documents

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.