17017-66-2Relevant articles and documents
Design, synthesis and biological evaluation of novel indole-benzimidazole hybrids targeting estrogen receptor alpha (ER-α)
Singla, Ramit,Gupta, Kunj Bihari,Upadhyay, Shishir,Dhiman, Monisha,Jaitak, Vikas
, p. 206 - 219 (2018)
In the course of efforts to develop novel selective estrogen receptor modulators (SERMs), indole-benzimidazole hybrids were designed and synthesised by fusing the indole nucleus with benzimidazole. All the compounds were first inspected for anti-prolifera
Design, synthesis and biological evaluation of novel indole-xanthendione hybrids as selective estrogen receptor modulators
Singla, Ramit,Gupta, Kunj Bihari,Upadhyay, Shishir,Dhiman, Monisha,Jaitak, Vikas
, p. 266 - 277 (2018)
Ground breaking clinical therapeutic advances in the treatment of breast cancer (BC) is the introduction of selective estrogen receptor modulators (SERMs). We have expeditiously designed and synthesized indole-xanthendione hybrids by coalescing the indole
Synthesis of Indolines by a Zn-Mediated Mannich Reaction/Pd-Catalyzed Amination Sequence
Presset, Marc,Pignon, Antoine,Paul, Jér?me,Le Gall, Erwan,Léonel, Eric,Martens, Thierry
, p. 3302 - 3310 (2017/03/23)
1,2-Disubstituted indolines have been prepared in fair to good yields by a Zn-mediated organometallic Mannich reaction, followed by an intramolecular Pd-catalyzed aromatic amination. The reactions are easy to set up and compatible with a large variety of simple or commercially available reagents. The method was further extended to the preparation of a 1,2,3-trisubstituted indoline.
