170238-94-5

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester
• CAS NO: 170238-94-5
• Molecular Formula: C20H19NO4
• Molecular Weight: 337.375
• Mol File: 170238-94-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester(170238-94-5)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester(170238-94-5)

Safety Data

• Hazardous Substances Data: 170238-94-5(Hazardous Substances Data)

Upstream product

• 181308-92-9 (E)-β-chloro-α,β-bis(4-methoxyphenyl)acrolein 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 284663-53-2 N,N-dimethyl 2-methoxycarbonyl-3,4-bis(p-methoxyphenyl)-1H-pyrrole-1-sulfonamide 
• 284663-39-4 N,N-dimethyl 2-methoxycarbonyl-3-iodo-4-(p-methoxyphenyl)-1H-pyrrole-1-sulfonamide 
• 284663-29-2 N,N-dimethyl 2-methoxycarbonyl-3,4-bis(trimethylsilyl)-1H-pyrrole-1-sulfonamide 
• 1337927-65-7 (E)-4,4'-(1-nitroethene-1,2-diyl)bis(4-methoxybenzene) 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 59019-40-8 1-[(1Z)-2-bromo-2-nitroethenyl]-4-methoxybenzene 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 2999-46-4 Ethyl isocyanoacetate 
• 6443-74-9 p-methoxy-α-p-methoxyphenylcinnamonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 343823-36-9 meso-2,3-bis(p-methoxyphenyl)succinonitrile 
• 2048-10-4 3,4-bis (4-methoxyphenyl)-1H-pyrrole 

Downstream Products

• 168010-02-4 methyl 3,4-bis(4-hydroxyphenyl)-1H-pyrrole-2-carboxylate 
• 1129697-15-9 2-methoxycarbonyl-3,4-di(4-methoxyphenyl)-N-4-methoxyphenylpyrrole 
• 170238-97-8 1H-3,7,8-tris(4-methoxyphenyl)pyrrolo<2,1-c><1,4>-oxazin-1-one 
• 144398-24-3 3,7,8-tris(4-hydroxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one 
• 170238-96-7 methyl 3,4-bis(4-methoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Cytotoxicity of substituted alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2- carboxylates in L1210 lymphoid leukemia cells

Two alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2-carboxylates proved to be potent cytotoxic agents in the murine L1210 lymphoid leukemia screen. DNA synthesis was preferentially inhibited with the major target of the agents being de novo purine biosynthesis at the regulatory enzyme sites of PRPP- amido transferase and IMP dehydrogenase. Other enzymatic activities which were suppressed by the drugs were DNA polymerase α, RNA polymerases, ribonucleoside reductase and dihydrofolate reductase. The d[NTP] pools, nucleoside kinase and the pyrimidine pathway were not affected by the presence of drugs. The DNA molecule itself was not the target of the agents, i.e. no alkylation of nucleotide bases, intercalation between bases or cross- linking of DNA strands occurred. The agents did cause L1210 DNA fragmentation after 24 h incubation at 100 μM.

Formation of 3,4-Diarylpyrrole- and Pyrrolocoumarin Core of Natural Marine Products via Barton–Zard Reaction and Selective O-Demethylation

A metal-free approach to 3,4-diarylpyrrole-2-carboxylate and pyrrolocoumarin cores of lamellarins and related natural products based on Barton–Zard reaction of nitrostilbenes with ethyl isocyanoacetate was developed. In the case of diarylpyrrole-2-carboxy

A direct phosphine-mediated synthesis of pyrroles from acid chlorides and α,β-unsaturated imines

A one-step method to assemble pyrroles from α,β-unsaturated imines and acid chlorides has been developed. This reaction is mediated by triphenylphosphine, which eliminates phosphine oxide to allow cyclization. This reaction has been employed to access a d