1704-15-0Relevant articles and documents
Metal complex and electroluminescent device comprising same
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Paragraph 0132-0135; 0146-0149, (2020/05/01)
Disclosed are a metal complex and an electroluminescent device comprising the same, wherein the metal complex contains a novel structure composed of a metal and a ligand. According to the invention, when the metal complex is applied to an electroluminescent device, especially in a hole injection layer, a hole transport layer and the like, the luminescent performance of the device can be improved,and the service life of the device can be effectively prolonged.
Facile access to 1,3-diketones by gold(i)-catalyzed regioselective hydration of ynones
Kuang, Jinqiang,Zhou, Tao,You, Tingjie,Chen, Jianhui,Su, Chenliang,Xia, Yuanzhi
supporting information, p. 3940 - 3944 (2019/04/30)
A facile and efficient synthesis of 1,3-diketones was developed by the gold(i)-catalyzed regioselective hydration of ynones at room temperature. This methodology employed 2.5 mol% of PPh3AuCl and 3 mol% of AgOTf as a simple catalytic system wit
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Deck, Lorraine M.,Hunsaker, Lucy A.,Vander Jagt, Thomas A.,Whalen, Lisa J.,Royer, Robert E.,Vander Jagt, David L.
supporting information, p. 854 - 865 (2017/12/13)
Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic potential. The transcription factor Nrf2 is a major regulator of phase II detoxification and anti-oxidant genes as well as anti-inflammatory and neuroprotective genes. Nrf2 is widespread in the CNS and is recognized as an important regulator of brain inflammation. The natural product curcumin exhibits numerous biological activities including ability to induce the expression of Nrf2-dependent phase II and anti-oxidant enzymes. Curcumin has been examined in a number of clinical studies with limited success, mainly owing to limited bioavailability and rapid metabolism. Enone analogues of curcumin were examined with an Nrf2 reporter assay to identify Nrf2 activators. Analogues were separated into groups with a 7-carbon dienone spacer, as found in curcumin; a 5-carbon enone spacer with and without a ring; and a 3-carbon enone spacer. Activators of Nrf2 were found in all three groups, many of which were more active than curcumin. Dose-response studies demonstrated that a range of substituents on the aromatic rings of these enones influenced not only the sensitivity to activation, reflected in EC50 values, but also the extent of activation, which suggests that multiple mechanisms are involved in the activation of Nrf2 by these analogues.
