170449-34-0 Usage
Description
2-PYRIDINESULFONYLACETONITRILE, also known as (Pyridin-2-ylsulphonyl)acetonitrile, is an organic compound that serves as a valuable intermediate in the synthesis of various chemical compounds. It is characterized by its unique chemical structure, which includes a pyridine ring and a sulfonyl group, making it a versatile building block in organic chemistry.
Uses
Used in Chemical Synthesis:
2-PYRIDINESULFONYLACETONITRILE is used as a reactant for the preparation of quaternary nitriles. Its application is based on the sulfone-?metal exchange and alkylation of pyridylsulfonyl nitriles, which allows for the creation of a diverse range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-PYRIDINESULFONYLACETONITRILE is used as a key intermediate in the synthesis of various drug candidates. Its unique chemical structure enables the development of novel compounds with potential therapeutic applications, contributing to the advancement of medicinal chemistry.
Used in Material Science:
2-PYRIDINESULFONYLACETONITRILE is also utilized in the field of material science, where it is employed in the development of new materials with specific properties. Its incorporation into the molecular structure of these materials can lead to enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 170449-34-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,4,4 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 170449-34:
(8*1)+(7*7)+(6*0)+(5*4)+(4*4)+(3*9)+(2*3)+(1*4)=130
130 % 10 = 0
So 170449-34-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O2S/c8-4-6-12(10,11)7-3-1-2-5-9-7/h1-3,5H,6H2
170449-34-0Relevant articles and documents
5-Substituted (1-Thiolan-2-yl)cytosines as inhibitors of A. aeolicus and E. coli ispe kinases: Very different affinities to similar substrate-binding sites
Schuetz, Andri P.,Locher, Sebastian,Bernet, Bruno,Illarionov, Boris,Fischer, Markus,Bacher, Adelbert,Diederich, Francois
supporting information, p. 880 - 887 (2013/03/14)
The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis are potential new targets for the development of selective drugs for the treatment of important infectious diseases. This pathway is used by major human pathogens, such as Plasmodium falciparum and Mycobacterium tuberculosis, but not by humans. The fourth enzyme in the pathway is the kinase IspE, and we report here the development and biological evaluation of new ligands for this enzyme from Escherichia coli and Aquifex aeolicus species as model systems for the pathogenic enzymes. The study focuses on analysis of the methylerythritol pocket of the 4-diphosphocytidyl-2-C-methyl-D-erythritol binding site. A series of 5-substituted 1-(thiolan-2-yl)cytosines with increasingly polar substituents were synthesized, opting for possible water-replacements in that sub-pocket as well as a high water-solubility of the ligands. In vitro studies showed IC 50 values in the micromolar range against E. coli IspE, but, unexpectedly, no inhibition against A. aeolicus IspE within the measurement range of the biological tests. Copyright