170701-40-3

Basic information

• Product Name: 1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole
• Synonyms: 1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole
• CAS NO: 170701-40-3
• Molecular Weight: 276.338
• Mol File: 170701-40-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole(170701-40-3)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-4, 9-dihydro-3H-pyrido[3,4-b]indole(170701-40-3)

Safety Data

• Hazardous Substances Data: 170701-40-3(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 61-54-1 tryptamine 
• 100-09-4 4-methoxybenzoic acid 
• 296797-76-7 2,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2-tosyl-1H-pyrido[3,4-b]indole 
• 3380-73-2 1-(4-methoxyphenyl)-1,2,3,4-tetrahydro-1H-pyrido[3,4-b]indole 

Downstream Products

• 1068158-72-4 (S)-1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 

Relevant articles and documents

Selectivity-tunable oxidation of tetrahydro-β-carboline over an OMS-2 composite catalyst: preparation and catalytic performance

Controlling the reaction selectivity of organic transformations without losing high conversion is always a challenge in catalytic processes. In this work, a H3PO4·12WO3/OMS-2 nanocomposite catalyst ([PW]-OMS-2) was prepared through the oxidation of a Mn(ii) salt with sodium phosphotungstate by KMnO4. Comprehensive characterization indicates that different Mn2+precursors significantly affected the crystalline phase and morphology of the as-synthesized catalysts and only MnSO4·H2O as the precursor could lead to a cryptomelane phase. Moreover, [PW]-OMS-2 demonstrated excellent catalytic activity toward aerobic oxidative dehydrogenation of tetrahydro-β-carbolines due to mixed crystalline phases, enhanced surface areas, rich surface oxygen vacancies and labile lattice oxygen species. In particular, β-carbolines and 3,4-dihydro-β-carbolines could be obtained from tetrahydro-β-carbolines with very high selectivity (up to 99%) over [PW]-OMS-2viatuning the reaction solvent and temperature. Under the present catalytic system, scalable synthesis of a β-carboline was achieved and the composite catalyst showed good stability and recyclability. This work not only clarified the structure-activity relationship of the catalyst, but also provided a practical pathway to achieve flexible, controllable synthesis of functional N-heterocycles.

Development of a metal-free amine oxidation method utilizing DEAD chemistry

Herein, we examine the oxidative abilities of azodicarboxylates for the conversion of amines to imines. This method provides access to synthetically useful imine intermediates including β-carbolines, quinazolines and N-heterocyclic carbene precursors. The ability to recover spent azodicarboxylate for regeneration and further use underscores the applicability and appeal of this protocol.

N-Bromo-succinimide promoted synthesis of β-carbolines and 3,4-dihydro-β-carbolines from tetrahydro-β-carbolines

Herein, we report a facile synthesis of 3,4-dihydro-β-carbolines and aromatic β-carbolines from tetrahydro-β-carbolines, mediated by N-bromosuccinimide in toluene at 0°C to room temperature (rt), in good to moderate yields.