17075-39-7

Basic information

• Product Name: Nsc290426
• Synonyms: Naphthalene, 1-chloro-4-methyl-;Nsc290426;1-Chloro-4-methylnaphthalene
• CAS NO: 17075-39-7
• Molecular Formula: C₁₁H₉Cl
• Molecular Weight: 176.64216
• Mol File: 17075-39-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 281.9°Cat760mmHg
• Flash Point: 125.5°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 0.00591mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: Nsc290426(CAS DataBase Reference)
• NIST Chemistry Reference: Nsc290426(17075-39-7)
• EPA Substance Registry System: Nsc290426(17075-39-7)

Safety Data

• Hazardous Substances Data: 17075-39-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

InChI:InChI=1/C11H9Cl/c1-8-6-7-11(12)10-5-3-2-4-9(8)10/h2-7H,1H3

Upstream product

• 4523-45-9 1-amino-4-methylnaphthalene 
• 90-12-0 1-Methylnaphthalene 
• 86-57-7 1-Nitronaphthalene 
• 676-58-4 methylmagnesium chloride 
• 97585-94-9 (4-Chloro-naphthalen-1-ylmethyl)-triphenyl-phosphonium; chloride 
• 7791-25-5 sulfuryl dichloride 
• 6627-78-7 1-bromo-4-methylnaphthalene 
• 1034050-52-6 4-chloronaphthalen-1-yl trifluoromethanesulfonate 
• 934-56-5 trimethyl(phenyl)stannane 

Downstream Products

• 5471-26-1 4-chloronaphthalenecarbaldehyde 
• 109297-22-5 4--1-naphthonitrile 
• 136613-48-4 4-chloro-2-naphthonitrile 
• 22531-51-7 ethyl 2-(2-methoxy-1-naphthyl)-2-oxoacetate 
• 101093-81-6 ethyl 4-methyl-1-naphthyloxoacetate 
• 4488-40-8 4-Methyl-1-naphthoic acid 
• 79996-98-8 1-bromomethyl-4-chloronaphthalene 

Relevant articles and documents

SURFACE PHOTOCHEMISTRY: THE PHOTO-CHLORINATION OF AROMATIC HYDROCARBONS WITH FERRIC CHLORIDE ON ALUMINA

Irradiation of a number of aromatic hydrocarbons adsorbed on alumina in the presence of ferric chloride leads to monochlorination.

Cobalt-Catalyzed Enantioselective C–H Arylation of Indoles

Atropoisomeric (hetero)biaryls are scaffolds with increasing importance in the pharmaceutical and agrochemical industries. Although it is the most obvious disconnection to construct such compounds, the direct enantioselective C–H arylation through the concomitant induction of the chiral information remains extremely challenging and uncommon. Herein, the unprecedented earth-abundant 3d-metal-catalyzed atroposelective direct arylation is reported, furnishing rare atropoisomeric C2-arylated indoles. Kinetic studies and DFT computation revealed an uncommon mechanism for this asymmetric transformation, with the oxidative addition being the rate- and enantio-determining step. Excellent stereoselectivities were reached (up to 96% ee), while using an unusual N-heterocyclic carbene ligand bearing an essential remote substituent. Attractive dispersion interactions along with positive C–H-π interactions exerted by the ligand were identified as key factors to guarantee the excellent enantioselection.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.