170858-34-1

Basic information

• Product Name: 4-(4-{2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethyl}piperazin-1-yl)benzenesulfonamide methanesulfonate (1:1)
• Synonyms: U 101387G;sonepiprazole Mesylate;4-[4-[2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide
• CAS NO: 170858-34-1
• Molecular Formula: C₂₂H₃₁N₃O₆S₂
• Molecular Weight: 497.628
• Mol File: 170858-34-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 613.9°C at 760 mmHg
• Flash Point: 325.1°C
• Vapor Pressure: 5.27E-15mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(4-{2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethyl}piperazin-1-yl)benzenesulfonamide methanesulfonate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-{2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethyl}piperazin-1-yl)benzenesulfonamide methanesulfonate (1:1)(170858-34-1)
• EPA Substance Registry System: 4-(4-{2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethyl}piperazin-1-yl)benzenesulfonamide methanesulfonate (1:1)(170858-34-1)

Safety Data

• Hazardous Substances Data: 170858-34-1(Hazardous Substances Data)

Usage

Description

4-(4-2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethylpiperazin-1-yl)benzenesulfonamide methanesulfonate (1:1) is a complex organic compound with a chemical structure that includes a benzene ring, a sulfonamide group, and a piperazine ring. It is characterized by its selective D4 dopamine antagonist properties and its ability to induce c-fos gene expression in the medial prefrontal cortex, similar to the effects of Clozapine.

Uses

Used in Pharmaceutical Industry:
4-(4-2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethylpiperazin-1-yl)benzenesulfonamide methanesulfonate (1:1) is used as a selective D4 dopamine antagonist for its low affinity at other monoamine receptors (Ki > 2000 nM). This property makes it a potential candidate for the development of new drugs targeting dopamine-related disorders.
Used in Antipsychotic Applications:
As an antipsychotic agent, 4-(4-2-[(1S)-3,4-dihydro-1H-isochromen-1-yl]ethylpiperazin-1-yl)benzenesulfonamide methanesulfonate (1:1) acts as a dopamine D4 antagonist, which can be beneficial in the treatment of various psychiatric conditions. Its ability to induce c-fos gene expression in the medial prefrontal cortex, similar to Clozapine, suggests that it may have potential therapeutic effects in treating conditions such as schizophrenia and other psychotic disorders.

Relevant articles and documents

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