17086-28-1 Usage
Description
Doxycycline monohydrate is a semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is the monohydrate form of doxycycline, characterized by its yellow, crystalline powder appearance. Doxycycline monohydrate is soluble in ethanol or methanol, has a high degree of lipid solubility, a low affinity for calcium binding, and is highly stable in normal human serum. It is very slightly soluble in water and is known for its ability to penetrate bacterial cells, interfere with protein biosynthesis, and exhibit antibiotic activity against various microorganisms, including Mycoplasma, Chlamydia, and Ricketsiae.
Uses
1. Used in Pharmaceutical Industry:
Doxycycline monohydrate is used as an antibiotic and antimicrobial agent for the treatment of a wide range of bacterial infections. It inhibits bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome, making it effective against various pathogens.
2. Used in Treatment of Malaria:
Doxycycline monohydrate is used as an antimalarial drug for the treatment of chloroquine-resistant falciparum malaria, providing an alternative treatment option for this life-threatening disease.
3. Used in Treatment of Acne:
Doxycycline monohydrate is used as a treatment for acne due to its antimicrobial properties, which help in reducing the bacterial load responsible for the inflammation and formation of acne lesions.
4. Used in Treatment of Lyme Disease, Chlamydia, and Rocky Mountain Spotted Fever:
Doxycycline monohydrate is used as a bacteriostatic antibiotic for the treatment of Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections.
5. Used in Inducible Systems for Gene Expression:
In yeast cells, doxycycline monohydrate has been used in doxycycline-inducible systems for the overexpression of specific proteins, such as methyltransferase Hmt1 (hnRNP methyltransferase 1) and interferon-induced transmembrane (IFITM) cell lines. This application allows for the controlled expression of genes, which is crucial in understanding their functions and potential therapeutic applications.
Brand Names:
Some of the brand names for Doxycycline monohydrate include Doxychel (Rachelle), Monodox (Oclassen), Oracea (CollaGenex), and Vibramycin (Pfizer).
Indications
Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics.
Biological Activity
Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Check Digit Verification of cas no
The CAS Registry Mumber 17086-28-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,8 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17086-28:
(7*1)+(6*7)+(5*0)+(4*8)+(3*6)+(2*2)+(1*8)=111
111 % 10 = 1
So 17086-28-1 is a valid CAS Registry Number.
