170872-48-7

Basic information

• Product Name: 1-(3-benzyloxy-2-hydroxypropyl)-5-bromo-6-azauracil
• CAS NO: 170872-48-7
• Molecular Weight: 356.176
• Mol File: 170872-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-benzyloxy-2-hydroxypropyl)-5-bromo-6-azauracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-benzyloxy-2-hydroxypropyl)-5-bromo-6-azauracil(170872-48-7)
• EPA Substance Registry System: 1-(3-benzyloxy-2-hydroxypropyl)-5-bromo-6-azauracil(170872-48-7)

Safety Data

• Hazardous Substances Data: 170872-48-7(Hazardous Substances Data)

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 4956-05-2 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 

Relevant articles and documents

Synthesis of racemic 5-substituted 1-(2,3-dihydroxypropyl)-6-azauracils and their isosteric isomers

Acyclic nucleoside analogues of antiviral DHPA and HPMPA have been prepared. Coupling of silylated 6-azauracils with benzyl glycidyl ether and stannic chloride followed by the deprotection with boron trichloride gave 1- (2,3-dihydroxypropyl)-6-azauracils (3) in good overall yields. Reaction of silylated 6-azauracil and epichlorohydrin with or without catalytic stannic chloride afforded 1-(2-chloro-3-hydroxypmpyl)-6-azauracil (4a) and 1-(3- chloro-2-hydroxypropyl)-6-azauracil (6a) respectively. Coupling of silylated 6-azaisocytosine under the same reaction conditions provided 1-(2,3- dihydroxypropyl)-6-azaisocytosine (9) and 1-(2-chloro-3-hydroxypropyl)-6- azaisocytosine (10) respectively. None of the compounds exhibited significant antiviral activity against herpes simplex viruses.