170910-61-9

Basic information

• Product Name: 1-<4-(1,1,2,2-tetrafluoroethoxy)phenyl>-2-imidazolidinone
• Synonyms: 1-<4-(1,1,2,2-tetrafluoroethoxy)phenyl>-2-imidazolidinone
• CAS NO: 170910-61-9
• Molecular Weight: 278.206
• Mol File: 170910-61-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-<4-(1,1,2,2-tetrafluoroethoxy)phenyl>-2-imidazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-<4-(1,1,2,2-tetrafluoroethoxy)phenyl>-2-imidazolidinone(170910-61-9)
• EPA Substance Registry System: 1-<4-(1,1,2,2-tetrafluoroethoxy)phenyl>-2-imidazolidinone(170910-61-9)

Safety Data

• Hazardous Substances Data: 170910-61-9(Hazardous Substances Data)

Upstream product

• 1026312-14-0 1-(2,2-diethoxy-ethyl)-3-[4-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-urea 
• 222712-67-6 [4-(1,1,2,2-Tetrafluoro-ethoxy)-phenyl]-carbamic acid phenyl ester 
• 155431-83-7 1-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 

Downstream Products

• 169169-37-3 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-imidazolidinone 

Relevant articles and documents

Optically active antifungal azoles. VIII synthesis and antifungal activity of 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1- methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-substituted phenyl)2(1H,3H)- imidazolones and 2-imidazolidinones

New optically active antifungal azoles, 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4- substituted phenyl)-2(1H,3H)-imidazolones (1, 2) and 2-imidazolidinones (3, 4), were prepared in a stereocontrolled manner from (1S)-1-[(2R)-2-(2,4- difluoro- and 2-fluorophenyl)-2-oxi-ranyl]ethanols (15, 16). Compounds 1 - 4 showed potent antifungal activity against Candida albicans in vitro and in vivo, as well as a broad antifungal spectrum for various fungi in vitro. Furthermore, the imidazolidinones, 3b - e and 4d, e, were found to exert extremely strong growth-inhibitory activity against Aspergillus fumigatus.