170946-03-9

Basic information

• Product Name: 2-Amino-6-<2-(2,5-dimethoxyphenyl)ethyl>nicotinsaeurenitril
• CAS NO: 170946-03-9
• Molecular Weight: 283.33
• Mol File: 170946-03-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Amino-6-<2-(2,5-dimethoxyphenyl)ethyl>nicotinsaeurenitril(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-<2-(2,5-dimethoxyphenyl)ethyl>nicotinsaeurenitril(170946-03-9)
• EPA Substance Registry System: 2-Amino-6-<2-(2,5-dimethoxyphenyl)ethyl>nicotinsaeurenitril(170946-03-9)

Safety Data

• Hazardous Substances Data: 170946-03-9(Hazardous Substances Data)

Upstream product

• 55244-11-6 ethyl cyanoacetimidate hydrochloride 
• 118709-30-1 trans-1-(2,5-dimethoxyphenyl)-2-buten-3-one 

Relevant articles and documents

Synthesis and antitumor activity of iso-piritrexim, a lipophilic folate antagonist

Two strategies towards the synthesis of Iso-Piritrexim (12) are described. A) The Mannich-reaction of ketone 2 yields the bases 4-HCl and 5-HCl. By means of LC base 4 is separated and treated with in situ generated 3,3-diaminoacrylonitrile (9) to yield the 2-aminonicotinonitrile 11. The cyclocondensation of 11 with guanidine provides Iso-PTX (12). B) Reduction and oxidation of the β-ketoester 15 leads to the β-ketoaldehyde 17, which is cyclocondensed with 2,4,6-triaminopyrimidine (18) to yield Iso-PTX (12). In the NCl-tumor-test Iso-PTX (12) shows a moderate activity against some leukemia and lung cancer cell lines.