170955-80-3Relevant articles and documents
Growth inhibition of Cryptococcus neoformans by 2-(1-piperazinyl)-5-(1,2-diarylethyl)-4,6-dichloropyrimidines: Synthesis and in vitro studies
Fellahi,Mandin,Dubois,Ombetta-Goka,Guenzet,Chaumont,Frangin
, p. 77 - 81 (2007/10/03)
2-(1-Piperazinyl)-5-[1-(4-chlorophenyl)-2-phenylethyl]-4,6-dichloropyrimide and 2-(1-piperazinyl)-5-[1-(4-chlorophenyl)-2-(3-chlorophenyl)ethyl]-4,6 -dichloropyrimidine were synthesized via organozinc reagents. These new pyrimidine derivatives were tested against human mycoflora. Biological tests showed that these compounds are selective growth inhibitors of Cryptococcus neoformans.