170956-92-0Relevant articles and documents
Copper-catalyzed aerobic oxidative carbocyclization-ketonization cascade: Selective synthesis of quinolinones
Xie, Peng,Wang, Zhi-Qiang,Deng, Guo-Bo,Song, Ren-Jie,Xia, Jia-Dong,Hu, Ming,Li, Jin-Heng
, p. 2257 - 2262 (2013)
A new thematic extension method is described for the carbocyclization of α-C(sp3)-H bonds of amides with alkynes followed by ketonization of the alkynes that utilizes the inexpensive copper(II) acetoacetonate [Cu(acac)2] as catalyst
Visible-Light-Mediated [2+2+1] Carbocyclization Reactions of 1,7-Enynes with Bromofluoroacetate to Form Fused Monofluorinated Cyclopenta[ c]quinolin-4-ones
Li, Yongqiang,Liu, Yuxiu,Qu, Yi,Song, Hongjian,Wang, Qingmin,Xu, Wentao,Zhang, Jingjing
, p. 5379 - 5389 (2020/05/19)
Herein, we describe a new protocol for photoinduced radical [2+2+1] carbocyclization reactions of 1,7-enynes with bromofluoroacetate. These reactions, which proceed via a cascade involving fluoroalkylation, 6-exo-dig and 5-endo-trig cyclizations, H-transf
Copper-Catalyzed Annulation Cascades of Alkyne-Tethered α-Bromocarbonyls with Alkynes: An Access to Heteropolycycles
Liu, Bang,Yu, Jiang-Xi,Li, Yang,Li, Jin-Heng,He, De-Liang
supporting information, p. 2129 - 2132 (2018/04/30)
We here describe a new Cu-catalyzed annulation cascade of alkyne-tethered α-bromocarbonyls with common alkynes for the synthesis of various heteropolycycle frameworks, including 1H-benzo[de]quinolin-2(3H)-ones, 4H-dibenzo[de,g]quinolin-5(6H)-one, and benzo[de]chromen-2(3H)-one, which were constructed with high selectivity. This was achieved by two-component annulation cascades, rather than atom-transfer radical cyclization (ATRC), with alkyne-tethered α-bromocarbonyls for one-step accessing heteropolycycles via C-Br bond split, intramolecular cyclization, intermolecular [4 + 2] annulation, and aryl C(sp2)-H functionalization cascades.