17100-53-7

Basic information

• Product Name: Benzene, 1-broMo-4-[(4-Methylphenyl)Methyl]-
• Synonyms: Benzene, 1-broMo-4-[(4-Methylphenyl)Methyl]-
• CAS NO: 17100-53-7
• Molecular Formula: C₁₄H₁₃Br
• Molecular Weight: 261
• Mol File: 17100-53-7.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzene, 1-broMo-4-[(4-Methylphenyl)Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-broMo-4-[(4-Methylphenyl)Methyl]-(17100-53-7)
• EPA Substance Registry System: Benzene, 1-broMo-4-[(4-Methylphenyl)Methyl]-(17100-53-7)

Safety Data

• Hazardous Substances Data: 17100-53-7(Hazardous Substances Data)

Usage

General Description

Benzene, 1-bromo-4-[(4-methylphenyl)methyl]- is a chemical compound with the molecular formula C15H13Br. It is commonly used in organic synthesis and pharmaceutical research due to its role as an intermediate in the production of various drugs and compounds. This chemical is an aromatic compound with a bromine atom attached to the 1-position and a 4-[(4-methylphenyl)methyl] group attached to the 4-position of the benzene ring. It is essential to handle this compound with caution as it may pose health hazards and should only be used by trained professionals in controlled laboratory environments.

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 108-88-3 toluene 
• 30203-84-0 1-bromo-4-(4-chlorobenzyl)benzene 
• 16160-46-6 1-Methoxy-2-(dimethyl-alanoxy)-ethan 
• 5720-05-8 4-methylphenylboronic acid 
• 910859-89-1 4-bromobenzyl diethyl phosphate 
• 15106-88-4 di(p-tolyl)zinc 
• 617-86-7 triethylsilane 
• 1122-91-4 4-bromo-benzaldehyde 
• 5142-75-6 tri(p-tolyl)bismuth 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 589-17-3 p-bromobenzyl chloride 
• 1410119-96-8 1-(4-bromobenzyloxy)octane 
• 57477-93-7 hydrazone of p-bromobenzaldehyde 

Downstream Products

• 76693-57-7 (4-bromophenyl)(p-tolyl)methanone 

Relevant articles and documents

Multi-component one-pot reaction of aromatic carbonyl compounds, tosylhydrazide, and arylboronic acids

In this paper, we developed a new method using 4-bromoacetophenone as the starting material, with tosylhydrazide and two arylboronic acids using Barluenga and Suzuki couplings in a four-component one-pot reaction to afford the target product 4-benzyl-1,1-biphenyls. This system that we have developed enables the use of easily accessible starting materials and can be employed on a wide variety of substrates with good functional group tolerance. In particular, this protocol can be applied to the synthesis of 4-(1-([1,1-biphenyl]-4-yl)ethyl)pyridine derivatives, a class of potential analogs of CPY17 inhibitors of prostate cancer.

Synthetic method of diarylmethanes

The invention discloses a synthetic method of diarylmethanes. The method is characterized in that benzyl pseudohalide and aromatic boric acid are reacted in an organic solvent under alkaline condition. The method employs easily available raw materials, conversion is realized under effect of no transition metal catalysis, water-free and oxygen-free are not required, Lewis acid catalysis is not required, the method has wide substrate universality, and various substituted diarylmethanes can be synthesized by the method.

Benzylic Phosphates in Friedel-Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes

Easily reachable electron-poor/rich primary and secondary benzylic phosphates are suitably used as substrates for Friedel-Crafts benzylation reactions with only 1.2 equiv activated/deactivated arenes (no additional solvent) to access structurally and electronically diverse polyarylated alkanes with excellent yields and selectivities at room temperature. Specifically, diversely substituted di/triarylmethanes are generated within 2-30 min using this approach. A wide number of electron-poor polyarylated alkanes are easily accomplished through this route by just tuning the phosphates.