17100-66-2

Basic information

• Product Name: 2H-Pyran, 2-[(2-bromophenyl)methoxy]tetrahydro-
• CAS NO: 17100-66-2
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• Mol File: 17100-66-2.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, 2-[(2-bromophenyl)methoxy]tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, 2-[(2-bromophenyl)methoxy]tetrahydro-(17100-66-2)
• EPA Substance Registry System: 2H-Pyran, 2-[(2-bromophenyl)methoxy]tetrahydro-(17100-66-2)

Safety Data

• Hazardous Substances Data: 17100-66-2(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 15852-73-0 (3-Bromophenyl)methanol 
• 18982-54-2 o-bromobenzyl alcohol 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 143888-92-0 2-[2-(2-Biphenyl-4-yl-oxiranyl)-benzyloxy]-tetrahydro-pyran 
• 133625-77-1 2-(1-methyl-2-propenyl)benzenemethanol 
• 82316-07-2 2-((Z)-but-2-en-1-yl)benzyl alcohol 
• 82316-08-3 2-((E)-but-2-en-1-yl)benzyl alcohol 
• 141938-57-0 2-(2-Benzyl-benzyloxy)-tetrahydro-pyran 
• 125593-21-7 Phenyl-[2-(tetrahydro-pyran-2-yloxymethyl)-phenyl]-methanol 
• 84801-07-0 2-(prop-2-enyl)benzyl alcohol 
• 34708-50-4 2-[(2-allylbenzyl)oxy]tetrahydro-2H-pyran 
• 84801-08-1 2-(2-propyn-1-yl)benzyl alcohol tetrahydropyranyl ether 
• 1026866-07-8 C₃₂H₃₈O₄ 
• 126535-05-5 2-{2-[2-(2,4-Dichloro-phenyl)-oxiranyl]-benzyloxy}-tetrahydro-pyran 
• 99948-47-7 2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)benzaldehyde 
• 173665-68-4 ethyl 2-oxo-2-[2-(tetrahydropyran-2-yloxymethyl)phenyl]acetate 
• 173665-69-5 2-oxo-N-methyl-2-[2-(tetrahydropyran-2-yloxymethyl)phenyl]acetamide 

Relevant articles and documents

Improved Hiyama cross-coupling reactions using HOMSi

Various parameters in the Hiyama cross-coupling reaction of HOMSi reagents with ethyl bromobenzoate were studied. These included solvent, ligand, palladium source, and added water. DMF and THF were found to be excellent solvents. Palladium chloride was found to be the best palladium source and no added water was required. The use of tri-o-tolylphosphine as the ligand proved to be particularly effective.

Macrocyclic Modulators of the Ghrelin Receptor

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

COMPOUNDS

Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.